Esmolol Hydrochloride Double Strength in plastic container
Clinical Indications
Rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in perioperative, postoperative, or emergent circumstances. Treatment of tachycardia and hypertension.
Dosing & Administration Rate
Loading dose (optional): 500 mcg/kg/min for 1 minute. Maintenance: 50-300 mcg/kg/min. Double strength (20 mg/mL) allows lower volume infusion in fluid-restricted patients.
Warnings & Precautions
Ultra-short acting beta-blocker (half-life 9 min). Risk of severe hypotension and bradycardia. Contraindicated in severe bradycardia, uncompensated heart failure, and cardiogenic shock.
Contraindications
Severe bradycardia. Uncompensated heart failure. Cardiogenic shock. Second- or third-degree AV block.
Pharmacology & Safety Profile
Mechanism of Action
Cardioselective beta-1-adrenergic receptor blocker with a very short duration of action. Decreases heart rate and cardiac output.
Adverse Reactions
Hypotension (common and sometimes severe), diaphoresis, dizziness, somnolence, confusion, bronchospasm (at high doses).
Compatibility Notes
Incompatible with sodium bicarbonate.
Electrolyte & Composition Profile
| Component | Amount / Concentration |
|---|---|
| Esmolol Hydrochloride | 20 mg/mL (Double Strength) |
| Sodium Chloride | 5.9 mg/mL |
| Sodium Acetate / Glacial Acetic Acid | Buffer |
| Water for Injection | q.s. |
| Caloric Density | 0 kcal/L |
Clinical Parameters
Clinical Disclaimer: Data compiled from FDA DailyMed, Baxter/Fresenius prescribing information, and USP monographs. Always verify against the physical product label, your institution's IV protocols, and current pharmacist guidance before administration.
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