This tool supports structured infectious-disease decision making but does not replace clinician judgement or local guideline pathways.
This OpiCalc infectious-disease entry reflects commonly used guideline criteria and bedside risk features used in contemporary clinical practice.
De-escalation Eligibility: IV-to-oral and spectrum de-escalation checklist after early response to therapy.
Afebrile / improving hemodynamics
+2 Points
Able to absorb oral medication
Source controlled
+1 Points
Cultures allow narrower therapy
Endocarditis / CNS / deep infection
-3 Points
Severe immunocompromise
-1 Points
Assessment Tier
Score 0
Complex infection features argue against early de-escalation.