This tool supports structured infectious-disease decision making but does not replace clinician judgement or local guideline pathways.
This OpiCalc infectious-disease entry reflects commonly used guideline criteria and bedside risk features used in contemporary clinical practice.
HCV Fibrosis APRI: Simple AST-to-platelet ratio index for advanced fibrosis screening in chronic hepatitis C.
AST above upper limit of normal
+2 Points
Platelets <150 ×10⁹/L
Portal hypertension features
Low albumin / synthetic dysfunction
+1 Points
Splenomegaly
Jaundice or decompensation history
Assessment Tier
Score 0
Advanced fibrosis is less likely from the selected profile.