Life-threatening organ dysfunction caused by a dysregulated host response to infection.
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
Sepsis-3 Criteria: Official consensus definition. Requires suspected infection + acute organ dysfunction (SOFA rise ≥2).
Suspected or Documented Infection
Source identified or highly probable
Acute SOFA rise ≥ 2 Points
Significant organ dysfunction from baseline
Vasopressors Required
To maintain MAP ≥ 65 mmHg
Lactate > 2 mmol/L (18 mg/dL)
Despite adequate fluid resuscitation