AGA IPMN Risk Stratification (2015)AIMS65 Score APACHE II (AP-specific application)ASGE Choledocholithiasis Risk Stratification ATLAS Score (CDI Treatment Response)Adenoma Detection Rate (ADR) Benchmark Amsterdam II Criteria (Lynch)Anorectal Manometry Interpretation (ARM)Aronchick Bowel Preparation Scale BISAP Score Barrett's Dysplasia Grading (Vienna Classification)Boston Bowel Preparation Scale (BBPS)Bristol Stool Form Scale CD Perianal Disease Activity Index (PDAI)CDI Severity Classification (IDSA/SHEA 2021)CT Severity Index (CTSI — Balthazar)Caecal Intubation Rate (CIR) Benchmark Cambridge Classification (CP — ERCP/EUS/CT)Celiac Disease Serology Interpreter Chicago Classification v4.0 (HRM)Colorectal Cancer TNM Staging (AJCC 8th Edition)Colorectal Submucosal Invasion (Haggitt / Kikuchi)Correa Cascade Staging Cotton Criteria (ERCP Complications)Crohn's Disease Activity Index (CDAI)Crohn's Disease Endoscopic Index of Severity (CDEIS)DeMeester Score (Reflux Monitoring)Distal Contractile Integral (DCI) Calculator Dukes / Modified Astler-Coller Staging (CRC)ERCP Post-Procedure Pancreatitis Risk Score ESD/EMR Curative Resection Criteria (Gastric)Eckardt Score (Achalasia)FODMAP Reintroduction Protocol Indicator Faecal Calprotectin Interpretation Faecal Incontinence Severity Index (FISI)Forrest Classification (Peptic Re-bleed Risk)Fukuoka Consensus Criteria (Pancreatic IPMN)Gastric Cancer TNM Staging (AJCC 8th)Gastric Emptying Scintigraphy Interpretation Glasgow-Blatchford Score (GBS)H. pylori Eradication Confirmation Algorithm Harmless Acute Pancreatitis Score (HAPS)Harvey-Bradshaw (HBI) to CDAI Conversion Harvey-Bradshaw Index (HBI)IBD Steroid Response Predictor (Oxford)IBS Rome IV Diagnostic Criteria IBS Symptom Severity Score (IBS-SSS)Integrated Relaxation Pressure (IRP) Interpreter JNET Classification (NBI Colonoscopy)Kudo Pit Pattern Classification Lichtiger Index (Modified Truelove & Witts)Los Angeles (LA) Classification (GORD)Lynch Syndrome Risk — Revised Bethesda Guidelines Lyon Consensus pH-Impedance Criteria (GORD)Lémann Index (Crohn's Digestive Damage)M-ANNHEIM Classification (Chronic Pancreatitis)MUST (Malnutrition Universal Screening Tool)Magnetic Resonance Index of Activity (MaRIA)Marsh Classification (Celiac Histopathology)Mayo Endoscopic Subscore (MES)Mayo Score (Ulcerative Colitis)Mirizzi Syndrome Classification (Csendes)Modified CT Severity Index (MCTSI)Montreal Classification (Crohn's Disease)Montreal Classification (Ulcerative Colitis)NICE Classification (NBI Polyp Lexicon)NOBLADS Score (Lower GI Bleeding)NRS-2002 (Nutritional Risk Screening)NSAID GI Risk Stratification (ACG/AGA)Nancy Histopathology Index (UC)Nutritional Risk Index (NRI)OLGA / OLGIM Staging (Gastric Gastritis)Oakland Score (Lower GI Bleeding)Oesophageal Cancer TNM Staging (AJCC 8th)Oxford Acute Severe Colitis Criteria (Travis)PREDICT Barrett's Risk Score Paris Classification (GI Lesion Morphology)Partial Mayo Score (UC)Prague C&M Classification (Barrett's)Ranson Criteria Robarts Histopathology Index (RHI)Rockall Score (Acute UGIB)Rutgeerts Score (Post-op Crohn's)SCCAI (Simple Clinical Colitis Activity Index)SIBO Breath Test Interpreter (Glucose/Lactulose)Serrated Lesion Classification (WHO 2019)Short Bowel Syndrome Classification (ESPEN)Siewert Classification (OGJ Tumours)Simple Endoscopic Score for Crohn's Disease (SES-CD)Strate Score (Diverticular Bleed)TPMT / NUDT15 Phenotype-to-Dose Adjustment Thiopurine Metabolite Interpreter Tokyo Guidelines 2018 (Cholangitis Severity)Tokyo Guidelines 2018 (Cholecystitis Severity)Truelove & Witts Criteria UCEIS (UC Endoscopic Index of Severity)Vienna Classification (Crohn's)Wexner (Cleveland Clinic) Constipation Score Wexner Faecal Incontinence Score (CCFIS)Zar Score (CDI Severity Predictor)

Amsterdam II Criteria (Lynch)

Revised Amsterdam IIHereditary Non-Polyposis Colorectal Cancer

Familial Clusters

Molecular Screening

Assess the "3-2-1" rule to determine if the family tree suggestive of hereditary colorectal cancer syndromes.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

Initial screening of families with suspected Lynch Syndrome (HNPCC)

To identify pedigrees requiring germline mismatch repair (MMR) gene testing

To trigger genetic counselling in families with early-onset or multiple GI/endometrial cancers

Cancer Types Included

Lynch-associated cancers: Colorectal, Endometrial, Small Bowel, Ureter, or Renal Pelvis. Amsterdam II (1999) expanded the original criteria (1990) to include these extra-colonic sites.

When to Use Bethesda or PREMM5 Instead

Small families — Amsterdam criteria are often too restrictive for modern small nuclear families

Symptomatic individuals with late-onset cancer — Revised Bethesda is better for single-patient screening

When quantitative risk estimate is needed — PREMM5 provides a percentage risk; Amsterdam is binary (Met/Not Met)

Last Comprehensive Review: 2026

Related Gastroenterology Tools

Short Bowel Syndrome Classification

Tokyo Guidelines 2018

Gastric Emptying Scintigraphy Interpretation

Barrett's Dysplasia Grading

Modified CT Severity Index

Montreal Classification

SIBO Breath Test Interpreter

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