4-domain severity assessment for UC. Remission= score ≤ 2 with no subscore > 1. Industry standard for clinical trial endpoints since 1987.
Stool Frequency
Rectal Bleeding
Endoscopic Subscore (Mayo Endoscopic Subscore)
Physician's Global Assessment
Verified
Last Review: 2026-07-17
| Score ≤ 2 | Clinical Remission (with endoscopic subscore 0 or 1) |
| Score 3–5 | Mild Activity |
| Score 6–10 | Moderate Activity |
| Score 11–12 | Severe / Fulminant Activity |
Schroeder KW et al. • New England Journal of Medicine. 1987;317(26):1625-9. The definitive establishment of the score.
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Last Comprehensive Review: 2026-07-17
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