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Calculated equivalencies are mathematical constructs. Due to incomplete cross-tolerance, the calculated target dose MUST ALWAYS be reduced by 25-50% to prevent fatal overdose during rotation.
Calculated Total MME/Day
15.0 MME
Safe Target Dose (24h)
11.3 mg
Reflects 25% algorithmic reduction from raw mathematical equivalent (15.0 mg).
Verified
Last Review: 2026
Last Comprehensive Review: 2026