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Registry Hub

Therapeutic Classification

alkylating agent Registry

Clinical reference for alkylating agent medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (alkylating agent)

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.

MedicationTherapeutic ClassMaternal Safety

ALKERAN

Comprehensive clinical and safety monograph for ALKERAN (ALKERAN).

Alkylating Agent Antineoplastic

caution

BELRAPZO

Comprehensive clinical and safety monograph for BELRAPZO (BELRAPZO).

Alkylating Agent

caution

BENDAMUSTINE HYDROCHLORIDE

Inhibitors of CYP1A2 may increase bendamustine exposure Myelosuppression is common monitor blood counts regularly Infusion reactions and skin reactions may occur.

Alkylating Agent

avoid

BENDEKA

Comprehensive clinical and safety monograph for BENDEKA (BENDEKA).

Alkylating Agent

caution

BICNU

Comprehensive clinical and safety monograph for BICNU (BICNU).

Alkylating Agent Antineoplastic

caution

BUSULFAN

Comprehensive clinical and safety monograph for BUSULFAN (BUSULFAN).

Alkylating Agent

caution

BUSULFEX

Comprehensive clinical and safety monograph for BUSULFEX (BUSULFEX).

Alkylating Agent

caution

CARBOPLATIN

Nephrotoxic drugs may enhance platinum-induced renal toxicity Myelosuppression is dose-related and is the dose-limiting toxicity.

Alkylating Agent

avoid

CARMUSTINE

Comprehensive clinical and safety monograph for CARMUSTINE (CARMUSTINE).

Alkylating Agent Antineoplastic

caution

CISPLATIN

Nephrotoxic drugs enhance cisplatin-induced kidney damage Ototoxicity is cumulative and may be severe and irreversible.

Alkylating Agent

avoid

CYCLOPHOSPHAMIDE

Allopurinol may increase the risk of leukopenia Can cause hemorrhagic cystitis and myelosuppression.

Alkylating Agent

avoid

CYTOXAN

Comprehensive clinical and safety monograph for CYTOXAN (CYTOXAN).

Alkylating Agent

caution

CYTOXAN (LYOPHILIZED)

Comprehensive clinical and safety monograph for CYTOXAN (LYOPHILIZED) (CYTOXAN (LYOPHILIZED)).

Alkylating Agent

caution

DACARBAZINE

Phenytoin may reduce efficacy Can cause severe nausea and vomiting and myelosuppression.

Alkylating Agent

avoid

EMCYT

Comprehensive clinical and safety monograph for EMCYT (EMCYT).

Alkylating Agent

caution

EVOMELA

Comprehensive clinical and safety monograph for EVOMELA (EVOMELA).

Alkylating Agent

caution

GLEOSTINE

Comprehensive clinical and safety monograph for GLEOSTINE (GLEOSTINE).

Alkylating Agent

caution

GLIADEL

Comprehensive clinical and safety monograph for GLIADEL (GLIADEL).

Alkylating Agent

caution

HEPZATO

Comprehensive clinical and safety monograph for HEPZATO (HEPZATO).

Alkylating Agent

caution

HEXALEN

Comprehensive clinical and safety monograph for HEXALEN (HEXALEN).

Alkylating Agent

caution

IFEX

Comprehensive clinical and safety monograph for IFEX (IFEX).

Alkylating Agent

caution

IFEX/MESNEX KIT

Comprehensive clinical and safety monograph for IFEX/MESNEX KIT (IFEX/MESNEX KIT).

Alkylating Agent with Uroprotective Agent

caution

IFOSFAMIDE

Other bone marrow suppressants may have additive effects Can cause hemorrhagic cystitis (requires Mesna) and neurotoxicity.

Alkylating Agent

avoid

LEUKERAN

Comprehensive clinical and safety monograph for LEUKERAN (LEUKERAN).

Antineoplastic (Alkylating Agent)

caution

LOMUSTINE

Other bone marrow suppressants may have additive effects Can cause delayed myelosuppression and pulmonary fibrosis.

Alkylating Agent

avoid

LYOPHILIZED CYTOXAN

Comprehensive clinical and safety monograph for LYOPHILIZED CYTOXAN (LYOPHILIZED CYTOXAN).

Alkylating agent

caution

MELPHALAN

Other bone marrow suppressants may have additive effects Can cause severe myelosuppression and secondary malignancies.

Alkylating Agent

avoid

MELPHALAN HYDROCHLORIDE

Other bone marrow suppressants may have additive effects Can cause severe myelosuppression and secondary malignancies.

Alkylating Agent

avoid

MUSTARGEN

Comprehensive clinical and safety monograph for MUSTARGEN (MUSTARGEN).

Alkylating Agent

caution

NEOSAR

Comprehensive clinical and safety monograph for NEOSAR (NEOSAR).

Alkylating Agent

caution

OXALIPLATIN

Other nephrotoxic drugs may enhance platinum-induced renal toxicity Can cause peripheral sensory neuropathy and pharyngolaryngeal dysesthesia.

Alkylating Agent

avoid

TEMODAR

Comprehensive clinical and safety monograph for TEMODAR (TEMODAR).

Antineoplastic (alkylating agent)

caution

TEMOZOLOMIDE

Valproic acid may decrease clearance Can cause severe myelosuppression and pneumocystis pneumonia prophylaxis is required.

Alkylating Agent

avoid

TEPADINA

Comprehensive clinical and safety monograph for TEPADINA (TEPADINA).

Antineoplastic (alkylating agent)

caution

TEPYLUTE

Comprehensive clinical and safety monograph for TEPYLUTE (TEPYLUTE).

Alkylating Agent

caution

THIOTEPA

Other bone marrow suppressants may have additive effects Can cause severe myelosuppression.

Alkylating Agent

avoid

TREANDA

Comprehensive clinical and safety monograph for TREANDA (TREANDA).

Alkylating Agent

caution

URACIL MUSTARD

Comprehensive clinical and safety monograph for URACIL MUSTARD (URACIL MUSTARD).

Alkylating Agent

caution

VALCHLOR

Comprehensive clinical and safety monograph for VALCHLOR (VALCHLOR).

Alkylating Agent

caution

VIVIMUSTA

Comprehensive clinical and safety monograph for VIVIMUSTA (VIVIMUSTA).

Alkylating Agent

caution

ZEPZELCA

Comprehensive clinical and safety monograph for ZEPZELCA (ZEPZELCA).

Alkylating Agent

caution