Therapeutic Classification

alpha Registry

Clinical reference for alpha medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (alpha)

Medication	Therapeutic Class	Maternal Safety
ABRILADA Comprehensive clinical and safety monograph for ABRILADA (ABRILADA).	TNF-Alpha Inhibitor	caution
ACARBOSE Comprehensive clinical and safety monograph for ACARBOSE (ACARBOSE).	Alpha-Glucosidase Inhibitor	caution
ALDOCLOR-150 Comprehensive clinical and safety monograph for ALDOCLOR-150 (ALDOCLOR-150).	Antihypertensive Combination (Central Alpha Agonist and Thiazide Diuretic)	caution
ALDOCLOR-250 Comprehensive clinical and safety monograph for ALDOCLOR-250 (ALDOCLOR-250).	Antihypertensive Combination (Central Alpha Agonist and Thiazide Diuretic)	caution
ALDOMET Comprehensive clinical and safety monograph for ALDOMET (ALDOMET).	Central Alpha Agonist Antihypertensive	caution
ALFUZOSIN HYDROCHLORIDE Comprehensive clinical and safety monograph for ALFUZOSIN HYDROCHLORIDE (ALFUZOSIN HYDROCHLORIDE).	Alpha-1 Blocker	caution
ALPHACAINE HYDROCHLORIDE W/ EPINEPHRINE Beta-blockers may antagonize cardiac effects and cause severe hypertension Can cause angina and arrhythmias in patients with heart disease.	Alpha/Beta Agonist	safe
ALPHAGAN Comprehensive clinical and safety monograph for ALPHAGAN (ALPHAGAN).	Alpha-2 Agonist	caution
ALPHAGAN P Comprehensive clinical and safety monograph for ALPHAGAN P (ALPHAGAN P).	Alpha-2 Adrenergic Agonist (Ophthalmic)	caution
AMJEVITA Comprehensive clinical and safety monograph for AMJEVITA (AMJEVITA).	TNF-alpha Inhibitor	caution
APRACLONIDINE HYDROCHLORIDE CNS depressants may enhance sedative effects Abrupt discontinuation can cause rebound hypertension and nervousness.	Alpha-2 Agonist	safe
ARTICAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE Beta-blockers may antagonize cardiac effects and cause severe hypertension Can cause angina and arrhythmias in patients with heart disease.	Alpha/Beta Agonist	safe
AVODART Comprehensive clinical and safety monograph for AVODART (AVODART).	5-Alpha-Reductase Inhibitor	caution
AVSOLA Comprehensive clinical and safety monograph for AVSOLA (AVSOLA).	TNF-Alpha Inhibitor	caution
BRIMONIDINE TARTRATE CNS depressants may potentiate effects MAOIs may potentiate vasoconstrictive effect May cause fatigue and drowsiness in some patients.	Alpha-2 Adrenergic Agonist	safe
BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE Beta-blockers may antagonize cardiac effects and cause severe hypertension Can cause angina and arrhythmias in patients with heart disease.	Alpha/Beta Agonist	safe
CARDURA Comprehensive clinical and safety monograph for CARDURA (CARDURA).	Alpha-1 Blocker Antihypertensive	caution
CARDURA XL Comprehensive clinical and safety monograph for CARDURA XL (CARDURA XL).	Alpha-1 Blocker Antihypertensive	caution
CARVEDILOL Other drugs that lower heart rate or blood pressure can have additive effects Abrupt withdrawal may exacerbate angina pectoris or cause myocardial infarction.	Alpha/Beta-Blocker	caution
CARVEDILOL PHOSPHATE Other drugs that lower heart rate or blood pressure can have additive effects Abrupt withdrawal may exacerbate angina pectoris or cause myocardial infarction.	Alpha/Beta-Blocker	caution
CATAPRES Comprehensive clinical and safety monograph for CATAPRES (CATAPRES).	Central Alpha-Agonist	caution
CATAPRES-TTS-1 Comprehensive clinical and safety monograph for CATAPRES-TTS-1 (CATAPRES-TTS-1).	Central Alpha-Agonist	caution
CATAPRES-TTS-2 Comprehensive clinical and safety monograph for CATAPRES-TTS-2 (CATAPRES-TTS-2).	Central Alpha-Agonist	caution
CATAPRES-TTS-3 Comprehensive clinical and safety monograph for CATAPRES-TTS-3 (CATAPRES-TTS-3).	Central Alpha-Agonist	caution
CIMZIA Comprehensive clinical and safety monograph for CIMZIA (CIMZIA).	TNF-alpha Inhibitor	caution
CLONIDINE CNS depressants may enhance sedative effects Abrupt discontinuation can cause rebound hypertension and nervousness.	Alpha-2 Agonist	safe
CLONIDINE HYDROCHLORIDE CNS depressants may enhance sedative effects Abrupt discontinuation can cause rebound hypertension and nervousness.	Alpha-2 Agonist	safe
CLONIDINE HYDROCHLORIDE AND CHLORTHALIDONE CNS depressants may enhance sedative effects Abrupt discontinuation can cause rebound hypertension and nervousness.	Alpha-2 Agonist	safe
COMBIGAN Comprehensive clinical and safety monograph for COMBIGAN (COMBIGAN).	Ophthalmic Antiglaucoma Agent (Alpha-2 Agonist + Beta Blocker)	caution
CYLTEZO Comprehensive clinical and safety monograph for CYLTEZO (CYLTEZO).	TNF-alpha Inhibitor	caution
DEXMEDETOMIDINE HYDROCHLORIDE Comprehensive clinical and safety monograph for DEXMEDETOMIDINE HYDROCHLORIDE (DEXMEDETOMIDINE HYDROCHLORIDE).	Alpha-2 Adrenergic Agonist Sedative	caution
DIBENIL Comprehensive clinical and safety monograph for DIBENIL (DIBENIL).	Alpha-Adrenergic Blocker	caution
DIBENZYLINE Comprehensive clinical and safety monograph for DIBENZYLINE (DIBENZYLINE).	Alpha-Adrenergic Blocker	caution
DOXAZOSIN MESYLATE Other antihypertensive drugs can have additive effects Can cause marked first-dose hypotension and syncope.	Alpha-1 Blocker	safe
DUPIXENT Comprehensive clinical and safety monograph for DUPIXENT (DUPIXENT).	Interleukin-4 Receptor Alpha Antagonist	caution
DURACLON Comprehensive clinical and safety monograph for DURACLON (DURACLON).	Alpha-2 Adrenergic Agonist	caution
DUTASTERIDE Strong CYP3A4 inhibitors may increase levels Pregnant women should not handle crushed capsules due to risk of fetal abnormality.	5-alpha Reductase Inhibitor	avoid
DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE Other antihypertensive drugs can have additive effects Can cause retrograde ejaculation and orthostatic hypotension.	Alpha-1 Blocker	safe
E-GLADES Comprehensive clinical and safety monograph for E-GLADES (E-GLADES).	Glaucoma Agent (Alpha-2 Agonist)	caution
ENBREL Comprehensive clinical and safety monograph for ENBREL (ENBREL).	TNF-alpha Inhibitor	caution
ENTADFI Comprehensive clinical and safety monograph for ENTADFI (ENTADFI).	5-Alpha Reductase Inhibitor and PDE5 Inhibitor	caution
EPINEPHRINE Beta-blockers may antagonize cardiac effects and cause severe hypertension Can cause angina and arrhythmias in patients with heart disease.	Alpha/Beta Agonist	safe
EPINEPHRINE (AUTOINJECTOR) Beta-blockers may antagonize cardiac effects and cause severe hypertension Can cause angina and arrhythmias in patients with heart disease.	Alpha/Beta Agonist	safe
ERELZI Comprehensive clinical and safety monograph for ERELZI (ERELZI).	TNF-alpha Inhibitor	caution
FINASTERIDE No significant drug interactions Pregnant women should not handle crushed tablets due to risk of fetal abnormality.	5-alpha Reductase Inhibitor	avoid
FLOMAX Comprehensive clinical and safety monograph for FLOMAX (FLOMAX).	Alpha-1 Blocker	caution
GALAFOLD Comprehensive clinical and safety monograph for GALAFOLD (GALAFOLD).	Alpha-Galactosidase A Pharmacological Chaperone	caution
GLYSET Comprehensive clinical and safety monograph for GLYSET (GLYSET).	Alpha-Glucosidase Inhibitor Antidiabetic	caution
GUANABENZ ACETATE Comprehensive clinical and safety monograph for GUANABENZ ACETATE (GUANABENZ ACETATE).	Centrally Acting Alpha-2 Agonist Antihypertensive	caution
GUANFACINE HYDROCHLORIDE CNS depressants may enhance sedative effects Abrupt discontinuation can cause rebound hypertension and nervousness.	Alpha-2 Agonist	safe
HADLIMA Comprehensive clinical and safety monograph for HADLIMA (HADLIMA).	TNF-alpha Inhibitor	caution
HUMIRA Comprehensive clinical and safety monograph for HUMIRA (HUMIRA).	TNF-alpha Inhibitor	caution
HYRIMOZ Comprehensive clinical and safety monograph for HYRIMOZ (HYRIMOZ).	TNF-alpha Inhibitor	caution
HYTRIN Comprehensive clinical and safety monograph for HYTRIN (HYTRIN).	Alpha-1 Blocker	caution
IDACIO Comprehensive clinical and safety monograph for IDACIO (IDACIO).	TNF-Alpha Inhibitor	caution
IGALMI Comprehensive clinical and safety monograph for IGALMI (IGALMI).	Alpha-2 Adrenergic Agonist	caution
INTUNIV Comprehensive clinical and safety monograph for INTUNIV (INTUNIV).	Alpha-2 Adrenergic Agonist for ADHD	caution
IOPIDINE Comprehensive clinical and safety monograph for IOPIDINE (IOPIDINE).	Alpha-2 Agonist	caution
JALYN Comprehensive clinical and safety monograph for JALYN (JALYN).	5-Alpha Reductase Inhibitor/Alpha-1 Blocker Combination	caution
KAPVAY Comprehensive clinical and safety monograph for KAPVAY (KAPVAY).	Alpha-2 Adrenergic Agonist	caution
Labetalol First-line oral antihypertensive for chronic hypertension in pregnancy and acute management of severe-range blood pressures (≥160/110 mmHg) alongside IV formulations. Extensive safety data; no consistent link to structural defects. Neonatal monitoring recommended when used at delivery.	Alpha/Beta-Blocker	safe
LABETALOL HYDROCHLORIDE Other drugs that lower heart rate or blood pressure can have additive effects Can cause liver injury and bronchospasm in susceptible patients.	Alpha/Beta-Blocker	safe
LABETALOL HYDROCHLORIDE IN DEXTROSE Other drugs that lower heart rate or blood pressure can have additive effects Can cause liver injury and bronchospasm in susceptible patients.	Alpha/Beta-Blocker	safe
LOFEXIDINE HYDROCHLORIDE Comprehensive clinical and safety monograph for LOFEXIDINE HYDROCHLORIDE (LOFEXIDINE HYDROCHLORIDE).	Alpha-2 Adrenergic Agonist	caution
LUCEMYRA Comprehensive clinical and safety monograph for LUCEMYRA (LUCEMYRA).	Alpha-2 Adrenergic Agonist	caution
LUMIFY Comprehensive clinical and safety monograph for LUMIFY (LUMIFY).	Alpha-2 Adrenergic Agonist	caution
LUMIFY PRESERVATIVE FREE Comprehensive clinical and safety monograph for LUMIFY PRESERVATIVE FREE (LUMIFY PRESERVATIVE FREE).	Alpha-2 Adrenergic Agonist	caution
MARCAINE HYDROCHLORIDE W/ EPINEPHRINE Beta-blockers may antagonize cardiac effects and cause severe hypertension Can cause angina and arrhythmias in patients with heart disease.	Alpha/Beta Agonist	safe
MARCAINE HYDROCHLORIDE W/ EPINEPHRINE PRESERVATIVE FREE Beta-blockers may antagonize cardiac effects and cause severe hypertension Can cause angina and arrhythmias in patients with heart disease.	Alpha/Beta Agonist	safe
METHYLDOPA Lithium may cause increased lithium toxicity Can cause hemolytic anemia and positive Coombs test.	Centrally Acting Alpha-2 Agonist	safe
METHYLDOPA AND CHLOROTHIAZIDE Lithium may cause increased lithium toxicity Can cause hemolytic anemia and positive Coombs test.	Centrally Acting Alpha-2 Agonist	safe
METHYLDOPA AND HYDROCHLOROTHIAZIDE Lithium may cause increased lithium toxicity Can cause hemolytic anemia and positive Coombs test.	Centrally Acting Alpha-2 Agonist	safe
METHYLDOPATE HCL Lithium may cause increased lithium toxicity Can cause hemolytic anemia and positive Coombs test.	Centrally Acting Alpha-2 Agonist	safe
METHYLDOPATE HYDROCHLORIDE Lithium may cause increased lithium toxicity Can cause hemolytic anemia and positive Coombs test.	Centrally Acting Alpha-2 Agonist	safe
MIDODRINE HYDROCHLORIDE Other vasoconstrictors can have additive effects Can cause supine hypertension and bradycardia.	Alpha-1 Agonist	safe
MIGLITOL Can reduce the bioavailability of digoxin and propranolol Can cause flatulence diarrhea and abdominal pain.	Alpha-Glucosidase Inhibitor	safe
MINIPRESS Comprehensive clinical and safety monograph for MINIPRESS (MINIPRESS).	Alpha-1 Blocker	caution
MINIPRESS XL Comprehensive clinical and safety monograph for MINIPRESS XL (MINIPRESS XL).	Alpha-1 Blocker	caution
MIRVASO Comprehensive clinical and safety monograph for MIRVASO (MIRVASO).	Alpha-2 Agonist (Topical)	caution
NEXICLON XR Comprehensive clinical and safety monograph for NEXICLON XR (NEXICLON XR).	Alpha-2 Adrenergic Agonist	caution
NOREPINEPHRINE BITARTRATE MAOIs can cause severe hypertension Extravasation can cause tissue necrosis and sloughing.	Alpha Agonist	safe
NOREPINEPHRINE BITARTRATE IN 0.9% SODIUM CHLORIDE No significant drug interactions Can cause hypernatremia and fluid overload.	Alpha Agonist	safe
NOREPINEPHRINE BITARTRATE IN 5% DEXTROSE MAOIs can cause severe hypertension Extravasation can cause tissue necrosis and sloughing.	Alpha Agonist	safe
NORTHERA Comprehensive clinical and safety monograph for NORTHERA (NORTHERA).	Sympathomimetic (Alpha-adrenergic Agonist)	caution
NYPOZI Comprehensive clinical and safety monograph for NYPOZI (NYPOZI).	TNF-alpha Inhibitor	caution
OBREDON Comprehensive clinical and safety monograph for OBREDON (OBREDON).	Beta blocker/alpha blocker	caution
ONYDA XR Comprehensive clinical and safety monograph for ONYDA XR (ONYDA XR).	Antihypertensive (Central Alpha Agonist)	caution
OXYMETAZOLINE MAOIs can cause hypertensive crisis Can cause rebound congestion (rhinitis medicamentosa) with prolonged use.	Alpha Agonist	safe
OXYMETAZOLINE HYDROCHLORIDE MAOIs can cause hypertensive crisis Can cause rebound congestion (rhinitis medicamentosa) with prolonged use.	Alpha Agonist	safe
PHENOXYBENZAMINE HYDROCHLORIDE Comprehensive clinical and safety monograph for PHENOXYBENZAMINE HYDROCHLORIDE (PHENOXYBENZAMINE HYDROCHLORIDE).	Alpha Blocker	caution
PHENTOLAMINE MESYLATE Comprehensive clinical and safety monograph for PHENTOLAMINE MESYLATE (PHENTOLAMINE MESYLATE).	Alpha Blocker	caution
PRAZOSIN HYDROCHLORIDE Other antihypertensive drugs can have additive effects Can cause marked first-dose hypotension and syncope.	Alpha-1 Blocker	safe
PRECOSE Comprehensive clinical and safety monograph for PRECOSE (PRECOSE).	Alpha-Glucosidase Inhibitor Antidiabetic	caution
PRILOCAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE Beta-blockers may antagonize cardiac effects and cause severe hypertension Can cause angina and arrhythmias in patients with heart disease.	Alpha/Beta Agonist	safe
PROAMATINE Comprehensive clinical and safety monograph for PROAMATINE (PROAMATINE).	Alpha-1 Agonist	caution
PROCAINE HYDROCHLORIDE W/ EPINEPHRINE Beta-blockers may antagonize cardiac effects and cause severe hypertension Can cause angina and arrhythmias in patients with heart disease.	Alpha/Beta Agonist	safe
PROPECIA Comprehensive clinical and safety monograph for PROPECIA (PROPECIA).	5-alpha reductase inhibitor	caution
PROSCAR Comprehensive clinical and safety monograph for PROSCAR (PROSCAR).	5-Alpha Reductase Inhibitor	caution
Q-PAM Comprehensive clinical and safety monograph for Q-PAM (Q-PAM).	Alpha-1 Blocker	caution
RAPAFLO Comprehensive clinical and safety monograph for RAPAFLO (RAPAFLO).	Alpha-1 Adrenergic Antagonist	caution
REGITINE Comprehensive clinical and safety monograph for REGITINE (REGITINE).	Alpha-Adrenergic Antagonist	caution
REMICADE Comprehensive clinical and safety monograph for REMICADE (REMICADE).	TNF-alpha Inhibitor	caution
RENFLEXIS Comprehensive clinical and safety monograph for RENFLEXIS (RENFLEXIS).	TNF-alpha Inhibitor	caution
RHOFADE Comprehensive clinical and safety monograph for RHOFADE (RHOFADE).	Topical Alpha-adrenergic Agonist	caution
RYZUMVI Comprehensive clinical and safety monograph for RYZUMVI (RYZUMVI).	Alpha-Adrenergic Blocker Ophthalmic	caution
SILODOSIN Other antihypertensive drugs can have additive effects Can cause retrograde ejaculation and orthostatic hypotension.	Alpha-1 Blocker	safe
SIMLANDI Comprehensive clinical and safety monograph for SIMLANDI (SIMLANDI).	TNF-alpha Inhibitor	caution
SIMPONI Comprehensive clinical and safety monograph for SIMPONI (SIMPONI).	TNF-alpha Inhibitor	caution
SIMPONI ARIA Comprehensive clinical and safety monograph for SIMPONI ARIA (SIMPONI ARIA).	TNF-alpha Inhibitor	caution
TAMSULOSIN HYDROCHLORIDE Other antihypertensive drugs can have additive effects Can cause retrograde ejaculation and orthostatic hypotension.	Alpha-1 Blocker	safe
TENEX Comprehensive clinical and safety monograph for TENEX (TENEX).	Alpha-2 adrenergic agonist	caution
TERAZOSIN HYDROCHLORIDE Other antihypertensive drugs can have additive effects Can cause marked first-dose hypotension and syncope.	Alpha-1 Blocker	safe
TIVORBEX Comprehensive clinical and safety monograph for TIVORBEX (TIVORBEX).	Muscle relaxant (alpha-2 agonist)	caution
TIZANIDINE HYDROCHLORIDE Strong CYP1A2 inhibitors (eg fluvoxamine) can significantly increase levels Can cause hypotension and sedation.	Alpha-2 Agonist	safe
UNIPRES Comprehensive clinical and safety monograph for UNIPRES (UNIPRES).	Alpha-1 Adrenergic Blocker	caution
UPNEEQ Comprehensive clinical and safety monograph for UPNEEQ (UPNEEQ).	Alpha-Adrenergic Agonist (Ophthalmic)	caution
UROXATRAL Comprehensive clinical and safety monograph for UROXATRAL (UROXATRAL).	Alpha-1 Blocker	caution
WYTENSIN Comprehensive clinical and safety monograph for WYTENSIN (WYTENSIN).	Alpha-2 Agonist Antihypertensive	caution
XYLOCAINE DENTAL WITH EPINEPHRINE Beta-blockers may antagonize cardiac effects and cause severe hypertension Can cause angina and arrhythmias in patients with heart disease.	Alpha/Beta Agonist	safe
XYLOCAINE W/ EPINEPHRINE Beta-blockers may antagonize cardiac effects and cause severe hypertension Can cause angina and arrhythmias in patients with heart disease.	Alpha/Beta Agonist	safe
YUFLYMA Comprehensive clinical and safety monograph for YUFLYMA (YUFLYMA).	TNF-alpha Inhibitor	caution
YUSIMRY Comprehensive clinical and safety monograph for YUSIMRY (YUSIMRY).	TNF-alpha Inhibitor	caution

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.