Therapeutic Classification

opioid Registry

Clinical reference for opioid medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (opioid)

Medication	Therapeutic Class	Maternal Safety
ABSTRAL Comprehensive clinical and safety monograph for ABSTRAL (ABSTRAL).	Opioid Analgesic	caution
ACEPHEN Comprehensive clinical and safety monograph for ACEPHEN (ACEPHEN).	Non-Opioid Analgesic	caution
ACETAMINOPHEN AND CODEINE PHOSPHATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
ACETAMINOPHEN AND HYDROCODONE BITARTRATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
ACETAMINOPHEN AND PENTAZOCINE HYDROCHLORIDE CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.	Opioid Agonist-Antagonist	safe
ACETAMINOPHEN, ASPIRIN, AND CODEINE PHOSPHATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
ACETAMINOPHEN, CAFFEINE AND DIHYDROCODEINE BITARTRATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
ACTIFED W/ CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
ACTIQ Comprehensive clinical and safety monograph for ACTIQ (ACTIQ).	Opioid Analgesic	caution
ALFENTA Comprehensive clinical and safety monograph for ALFENTA (ALFENTA).	Opioid Analgesic	caution
ALFENTANIL Comprehensive clinical and safety monograph for ALFENTANIL (ALFENTANIL).	Opioid Analgesic	caution
ALVIMOPAN Comprehensive clinical and safety monograph for ALVIMOPAN (ALVIMOPAN).	Peripherally Acting Mu-Opioid Receptor Antagonist	caution
ANEXSIA Comprehensive clinical and safety monograph for ANEXSIA (ANEXSIA).	Opioid Analgesic Combination	caution
ANEXSIA 5/325 Comprehensive clinical and safety monograph for ANEXSIA 5/325 (ANEXSIA 5/325).	Opioid Analgesic Combination	caution
ANEXSIA 7.5/325 Comprehensive clinical and safety monograph for ANEXSIA 7.5/325 (ANEXSIA 7.5/325).	Opioid Analgesic Combination	caution
ANEXSIA 7.5/650 Comprehensive clinical and safety monograph for ANEXSIA 7.5/650 (ANEXSIA 7.5/650).	Opioid Analgesic Combination	caution
APADAZ Comprehensive clinical and safety monograph for APADAZ (APADAZ).	Opioid Analgesic	caution
APOMORPHINE HYDROCHLORIDE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
ARYMO ER Comprehensive clinical and safety monograph for ARYMO ER (ARYMO ER).	Opioid Analgesic	caution
ARYNTA Comprehensive clinical and safety monograph for ARYNTA (ARYNTA).	Opioid Analgesic	caution
ASTRAMORPH PF Comprehensive clinical and safety monograph for ASTRAMORPH PF (ASTRAMORPH PF).	Opioid Analgesic	caution
ATROPINE AND DEMEROL Comprehensive clinical and safety monograph for ATROPINE AND DEMEROL (ATROPINE AND DEMEROL).	Opioid Analgesic Combination	caution
AVINZA Comprehensive clinical and safety monograph for AVINZA (AVINZA).	Opioid Analgesic	caution
BANCAP HC Comprehensive clinical and safety monograph for BANCAP HC (BANCAP HC).	Opioid Analgesic	caution
BELBUCA Comprehensive clinical and safety monograph for BELBUCA (BELBUCA).	Opioid Analgesic	caution
BIZENGRI Comprehensive clinical and safety monograph for BIZENGRI (BIZENGRI).	Opioid Analgesic	caution
BRIXADI Comprehensive clinical and safety monograph for BRIXADI (BRIXADI).	Opioid Partial Agonist	caution
BRYNOVIN Comprehensive clinical and safety monograph for BRYNOVIN (BRYNOVIN).	Opioid Partial Agonist	caution
BRYREL Comprehensive clinical and safety monograph for BRYREL (BRYREL).	Opioid Partial Agonist	caution
BUNAVAIL Comprehensive clinical and safety monograph for BUNAVAIL (BUNAVAIL).	Opioid Partial Agonist Combination	caution
BUPRENEX Comprehensive clinical and safety monograph for BUPRENEX (BUPRENEX).	Opioid Partial Agonist	caution
BUPRENORPHINE Benzodiazepines and other CNS depressants increase risk of respiratory depression Can precipitate withdrawal in patients dependent on other opioids.	Opioid Partial Agonist	caution
BUPRENORPHINE HYDROCHLORIDE Benzodiazepines and other CNS depressants increase risk of respiratory depression Can precipitate withdrawal in patients dependent on other opioids.	Opioid Partial Agonist	caution
BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
BUPRENORPHINE HYDROCHLORIDE; NALOXONE HYDROCHLORIDE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
BUTALBITAL, ASPIRIN, CAFFEINE, AND CODEINE PHOSPHATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
BUTORPHANOL TARTRATE Comprehensive clinical and safety monograph for BUTORPHANOL TARTRATE (BUTORPHANOL TARTRATE).	Opioid Analgesic	caution
BUTORPHANOL TARTRATE PRESERVATIVE FREE Comprehensive clinical and safety monograph for BUTORPHANOL TARTRATE PRESERVATIVE FREE (BUTORPHANOL TARTRATE PRESERVATIVE FREE).	Opioid Analgesic	caution
BUTRANS Comprehensive clinical and safety monograph for BUTRANS (BUTRANS).	Opioid Analgesic	caution
CAP-PROFEN Comprehensive clinical and safety monograph for CAP-PROFEN (CAP-PROFEN).	Opioid and NSAID Combination	caution
CAPITAL AND CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
CARISOPRODOL, ASPIRIN AND CODEINE PHOSPHATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
CO-GESIC Comprehensive clinical and safety monograph for CO-GESIC (CO-GESIC).	Opioid Analgesic Combination	caution
CODAMINE Comprehensive clinical and safety monograph for CODAMINE (CODAMINE).	Opioid Analgesic Combination	caution
Codeine Avoid. Codeine is a prodrug converted by CYP2D6 to morphine. Ultra-rapid metabolizers produce excessive morphine, posing risk of neonatal opioid toxicity. In 2017, the FDA contraindicated codeine (and tramadol) for breastfeeding mothers due to neonatal deaths from morphine toxicity in infants of ultra-rapid metabolizers. In pregnancy, opioids carry risk of Neonatal Opioid Withdrawal Syndrome (NOWS), fetal growth restriction, and preterm birth with chronic use. For acute pain in pregnancy, acetaminophen is preferred. Short-term use of codeine near term poses additional risk of neonatal respiratory depression.	Opioid Agonist	avoid
CODEINE SULFATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
CODEINE, ASPIRIN, APAP FORMULA NO. 2 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
CODEINE, ASPIRIN, APAP FORMULA NO. 3 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
CODEINE, ASPIRIN, APAP FORMULA NO. 4 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
COMBOGESIC Comprehensive clinical and safety monograph for COMBOGESIC (COMBOGESIC).	Analgesic Combination (Opioid + Non-Opioid)	caution
COMBOGESIC IV Comprehensive clinical and safety monograph for COMBOGESIC IV (COMBOGESIC IV).	Analgesic Combination (Opioid + Non-Opioid)	caution
COMBUNOX Comprehensive clinical and safety monograph for COMBUNOX (COMBUNOX).	Analgesic Combination (Opioid + NSAID)	caution
COMPOUND 65 Comprehensive clinical and safety monograph for COMPOUND 65 (COMPOUND 65).	Analgesic Combination (Opioid + NSAID)	caution
CONZIP Comprehensive clinical and safety monograph for CONZIP (CONZIP).	Opioid Analgesic	caution
DALGAN Comprehensive clinical and safety monograph for DALGAN (DALGAN).	Opioid Analgesic	caution
DARVOCET Comprehensive clinical and safety monograph for DARVOCET (DARVOCET).	Opioid Analgesic Combination	caution
DARVOCET A500 Comprehensive clinical and safety monograph for DARVOCET A500 (DARVOCET A500).	Opioid Analgesic Combination	caution
DARVOCET-N 100 Comprehensive clinical and safety monograph for DARVOCET-N 100 (DARVOCET-N 100).	Opioid Analgesic	caution
DARVOCET-N 50 Comprehensive clinical and safety monograph for DARVOCET-N 50 (DARVOCET-N 50).	Opioid Analgesic	caution
DARVON Comprehensive clinical and safety monograph for DARVON (DARVON).	Opioid Analgesic	caution
DARVON COMPOUND Comprehensive clinical and safety monograph for DARVON COMPOUND (DARVON COMPOUND).	Opioid Analgesic Combination	caution
DARVON COMPOUND-65 Comprehensive clinical and safety monograph for DARVON COMPOUND-65 (DARVON COMPOUND-65).	Opioid Analgesic Combination	caution
DARVON W/ ASA Comprehensive clinical and safety monograph for DARVON W/ ASA (DARVON W/ ASA).	Opioid Analgesic Combination	caution
DARVON-N Comprehensive clinical and safety monograph for DARVON-N (DARVON-N).	Opioid Analgesic	caution
DARVON-N W/ ASA Comprehensive clinical and safety monograph for DARVON-N W/ ASA (DARVON-N W/ ASA).	Opioid Analgesic Combination	caution
DEMEROL Comprehensive clinical and safety monograph for DEMEROL (DEMEROL).	Opioid Analgesic	caution
DEPODUR Comprehensive clinical and safety monograph for DEPODUR (DEPODUR).	Opioid Analgesic	caution
DILAUDID Comprehensive clinical and safety monograph for DILAUDID (DILAUDID).	Opioid Analgesic	caution
DILAUDID-HP Comprehensive clinical and safety monograph for DILAUDID-HP (DILAUDID-HP).	Opioid Analgesic	caution
DOLENE Comprehensive clinical and safety monograph for DOLENE (DOLENE).	Opioid Analgesic	caution
DOLENE AP-65 Comprehensive clinical and safety monograph for DOLENE AP-65 (DOLENE AP-65).	Opioid Analgesic Combination	caution
DOLISHALE Comprehensive clinical and safety monograph for DOLISHALE (DOLISHALE).	Opioid Analgesic	caution
DOLOPHINE HYDROCHLORIDE Comprehensive clinical and safety monograph for DOLOPHINE HYDROCHLORIDE (DOLOPHINE HYDROCHLORIDE).	Opioid Analgesic	caution
DSUVIA Comprehensive clinical and safety monograph for DSUVIA (DSUVIA).	Opioid Analgesic	caution
DURADYNE DHC Comprehensive clinical and safety monograph for DURADYNE DHC (DURADYNE DHC).	Opioid Analgesic	caution
DURAGESIC-100 Comprehensive clinical and safety monograph for DURAGESIC-100 (DURAGESIC-100).	Opioid Analgesic	caution
DURAGESIC-12 Comprehensive clinical and safety monograph for DURAGESIC-12 (DURAGESIC-12).	Opioid Analgesic	caution
DURAGESIC-25 Comprehensive clinical and safety monograph for DURAGESIC-25 (DURAGESIC-25).	Opioid Analgesic	caution
DURAGESIC-37 Comprehensive clinical and safety monograph for DURAGESIC-37 (DURAGESIC-37).	Opioid Analgesic	caution
DURAGESIC-50 Comprehensive clinical and safety monograph for DURAGESIC-50 (DURAGESIC-50).	Opioid Analgesic	caution
DURAGESIC-75 Comprehensive clinical and safety monograph for DURAGESIC-75 (DURAGESIC-75).	Opioid Analgesic	caution
DURAMORPH PF Comprehensive clinical and safety monograph for DURAMORPH PF (DURAMORPH PF).	Opioid Analgesic	caution
ELUXADOLINE Comprehensive clinical and safety monograph for ELUXADOLINE (ELUXADOLINE).	Opioid Receptor Modulator	caution
EMBEDA Comprehensive clinical and safety monograph for EMBEDA (EMBEDA).	Opioid Analgesic	caution
EMPRACET W/ CODEINE PHOSPHATE #3 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
EMPRACET W/ CODEINE PHOSPHATE #4 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
ENTEREG Comprehensive clinical and safety monograph for ENTEREG (ENTEREG).	Peripheral Opioid Antagonist	caution
EVZIO Comprehensive clinical and safety monograph for EVZIO (EVZIO).	Opioid Antagonist	caution
EVZIO (AUTOINJECTOR) Comprehensive clinical and safety monograph for EVZIO (AUTOINJECTOR) (EVZIO (AUTOINJECTOR)).	Opioid Antagonist	caution
EXALGO Comprehensive clinical and safety monograph for EXALGO (EXALGO).	Opioid Analgesic	caution
FENTANYL CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTANYL CITRATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTANYL CITRATE AND DROPERIDOL CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTANYL CITRATE PRESERVATIVE FREE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTANYL-100 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTANYL-12 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTANYL-25 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTANYL-37 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTANYL-50 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTANYL-62 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTANYL-75 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTANYL-87 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
FENTORA Comprehensive clinical and safety monograph for FENTORA (FENTORA).	Opioid Analgesic	caution
FIORICET W/ CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
FIORINAL W/CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
FYREMADEL Comprehensive clinical and safety monograph for FYREMADEL (FYREMADEL).	Opioid Analgesic	caution
HY-PHEN Comprehensive clinical and safety monograph for HY-PHEN (HY-PHEN).	Opioid Antitussive Combination	caution
HYCODAN Comprehensive clinical and safety monograph for HYCODAN (HYCODAN).	Opioid Antitussive	caution
HYCOFENIX Comprehensive clinical and safety monograph for HYCOFENIX (HYCOFENIX).	Opioid Antitussive	caution
HYDROCODONE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
HYDROCODONE BITARTRATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
HYDROCODONE BITARTRATE AND ACETAMINOPHEN CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
HYDROCODONE BITARTRATE AND ASPIRIN CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
HYDROCODONE BITARTRATE AND CHLORPHENIRAMINE MALEATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
HYDROCODONE BITARTRATE AND HOMATROPINE METHYLBROMIDE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
HYDROCODONE POLISTIREX AND CHLORPHENIRAMINE POLISTIREX CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
HYDROCODONE POLISTIREX AND CHLORPHENIRAMNE POLISTIREX CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
HYDROMORPHONE HYDROCHLORIDE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
INFUMORPH Comprehensive clinical and safety monograph for INFUMORPH (INFUMORPH).	Opioid Analgesic	caution
INJECTAPAP Comprehensive clinical and safety monograph for INJECTAPAP (INJECTAPAP).	Non-Opioid Analgesic	caution
INVAGESIC Comprehensive clinical and safety monograph for INVAGESIC (INVAGESIC).	Opioid Analgesic Combination	caution
INVAGESIC FORTE Comprehensive clinical and safety monograph for INVAGESIC FORTE (INVAGESIC FORTE).	Opioid Analgesic Combination	caution
IONSYS Comprehensive clinical and safety monograph for IONSYS (IONSYS).	Opioid Analgesic	caution
JOBEVNE Comprehensive clinical and safety monograph for JOBEVNE (JOBEVNE).	Opioid Analgesic	caution
KADIAN Comprehensive clinical and safety monograph for KADIAN (KADIAN).	Opioid Analgesic	caution
KESSO-GESIC Comprehensive clinical and safety monograph for KESSO-GESIC (KESSO-GESIC).	Opioid Analgesic Combination	caution
KLOXXADO Comprehensive clinical and safety monograph for KLOXXADO (KLOXXADO).	Opioid Antagonist	caution
KORSUVA Comprehensive clinical and safety monograph for KORSUVA (KORSUVA).	Kappa Opioid Receptor Agonist	caution
LAZANDA Comprehensive clinical and safety monograph for LAZANDA (LAZANDA).	Opioid Analgesic	caution
LERITINE Comprehensive clinical and safety monograph for LERITINE (LERITINE).	Opioid Analgesic	caution
LEVO-DROMORAN Comprehensive clinical and safety monograph for LEVO-DROMORAN (LEVO-DROMORAN).	Opioid Analgesic	caution
LEVORPHANOL TARTRATE Comprehensive clinical and safety monograph for LEVORPHANOL TARTRATE (LEVORPHANOL TARTRATE).	Opioid Analgesic	caution
LORCET-HD Comprehensive clinical and safety monograph for LORCET-HD (LORCET-HD).	Opioid analgesic combination	caution
LORFAN Comprehensive clinical and safety monograph for LORFAN (LORFAN).	Opioid antagonist	caution
LORTAB Comprehensive clinical and safety monograph for LORTAB (LORTAB).	Opioid analgesic combination	caution
MEPERGAN Comprehensive clinical and safety monograph for MEPERGAN (MEPERGAN).	Opioid Analgesic/Antiemetic Combination	caution
MEPERIDINE AND ATROPINE SULFATE MAOIs can cause serotonin syndrome and hyperpyrexia Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
MEPERIDINE HYDROCHLORIDE MAOIs can cause serotonin syndrome and hyperpyrexia Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE MAOIs can cause serotonin syndrome and hyperpyrexia Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
Methadone (MOUD) Standard-of-care MOUD for opioid use disorder in pregnancy. Methadone maintenance therapy reduces illicit drug use, stabilizes maternal physiology, and improves prenatal care engagement and fetal outcomes. Longer-established than buprenorphine in pregnancy with extensive outcome data. Requires daily observed dosing at an opioid treatment program (OTP). Associated with more severe and longer NOWS than buprenorphine. Dose changes required throughout pregnancy due to altered pharmacokinetics. Not the same as analgesic methadone use.	Opioid Agonist	safe
METHADONE HYDROCHLORIDE CYP450 inducers or inhibitors can significantly alter levels Can cause QT prolongation and life-threatening respiratory depression.	Opioid Agonist	avoid
METHADONE HYDROCHLORIDE INTENSOL CYP450 inducers or inhibitors can significantly alter levels Can cause QT prolongation and life-threatening respiratory depression.	Opioid Agonist	avoid
METHADOSE Comprehensive clinical and safety monograph for METHADOSE (METHADOSE).	Opioid Agonist	caution
METHYLNALTREXONE BROMIDE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Peripheral Opioid Receptor Antagonist	safe
MORPHABOND ER Comprehensive clinical and safety monograph for MORPHABOND ER (MORPHABOND ER).	Opioid Analgesic	caution
MORPHINE SULFATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
MORPHINE SULFATE (AUTOINJECTOR) CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
MOVANTIK Comprehensive clinical and safety monograph for MOVANTIK (MOVANTIK).	Peripherally Acting Mu-Opioid Receptor Antagonist	caution
MS CONTIN Comprehensive clinical and safety monograph for MS CONTIN (MS CONTIN).	Opioid Analgesic	caution
MYKACET Comprehensive clinical and safety monograph for MYKACET (MYKACET).	Opioid Analgesic Combination	caution
NALBUPHINE CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.	Opioid Agonist-Antagonist	safe
NALBUPHINE HYDROCHLORIDE CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.	Opioid Agonist-Antagonist	safe
NALMEFENE HYDROCHLORIDE Comprehensive clinical and safety monograph for NALMEFENE HYDROCHLORIDE (NALMEFENE HYDROCHLORIDE).	Opioid Antagonist	caution
NALOXEGOL Comprehensive clinical and safety monograph for NALOXEGOL (NALOXEGOL).	Opioid Antagonist	caution
NALOXONE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NALOXONE HCL No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NALOXONE HYDROCHLORIDE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NALOXONE HYDROCHLORIDE (AUTOINJECTOR) No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NALOXONE HYDROCHLORIDE AND PENTAZOCINE HYDROCHLORIDE CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.	Opioid Agonist-Antagonist	safe
NALTREXONE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NALTREXONE HYDROCHLORIDE No significant drug interactions Can precipitate acute withdrawal in patients dependent on opioids.	Opioid Antagonist	safe
NARCAN Comprehensive clinical and safety monograph for NARCAN (NARCAN).	Opioid Antagonist	caution
NORCET Comprehensive clinical and safety monograph for NORCET (NORCET).	Opioid Analgesic	caution
NORCO Comprehensive clinical and safety monograph for NORCO (NORCO).	Opioid Analgesic	caution
NOVRAD Comprehensive clinical and safety monograph for NOVRAD (NOVRAD).	Opioid Antitussive	caution
NUBAIN Comprehensive clinical and safety monograph for NUBAIN (NUBAIN).	Opioid Analgesic	caution
NUCYNTA Comprehensive clinical and safety monograph for NUCYNTA (NUCYNTA).	Opioid Analgesic	caution
NUCYNTA ER Comprehensive clinical and safety monograph for NUCYNTA ER (NUCYNTA ER).	Opioid Analgesic	caution
NUMORPHAN Comprehensive clinical and safety monograph for NUMORPHAN (NUMORPHAN).	Opioid Analgesic	caution
OFIRMEV Comprehensive clinical and safety monograph for OFIRMEV (OFIRMEV).	Non-opioid Analgesic	caution
OLINVYK Comprehensive clinical and safety monograph for OLINVYK (OLINVYK).	Opioid Analgesic	caution
ONSOLIS Comprehensive clinical and safety monograph for ONSOLIS (ONSOLIS).	Opioid Analgesic	caution
ONSURA Comprehensive clinical and safety monograph for ONSURA (ONSURA).	Peripherally-Acting Mu-Opioid Receptor Antagonist (PAMORA)	caution
OPANA Comprehensive clinical and safety monograph for OPANA (OPANA).	Opioid Analgesic	caution
OPANA ER Comprehensive clinical and safety monograph for OPANA ER (OPANA ER).	Opioid Analgesic	caution
OPVEE Comprehensive clinical and safety monograph for OPVEE (OPVEE).	Opioid Antagonist	caution
ORAMORPH SR Comprehensive clinical and safety monograph for ORAMORPH SR (ORAMORPH SR).	Opioid Analgesic	caution
ORLAAM Comprehensive clinical and safety monograph for ORLAAM (ORLAAM).	Opioid agonist	caution
ORLEX HC Comprehensive clinical and safety monograph for ORLEX HC (ORLEX HC).	Muscle relaxant/opioid combination	caution
OXAYDO Comprehensive clinical and safety monograph for OXAYDO (OXAYDO).	Opioid Analgesic	caution
OXTELLAR XR Comprehensive clinical and safety monograph for OXTELLAR XR (OXTELLAR XR).	Opioid Analgesic	caution
OXYCET Comprehensive clinical and safety monograph for OXYCET (OXYCET).	Opioid Analgesic Combination	caution
OXYCODONE 2.5/APAP 500 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
OXYCODONE 5/APAP 500 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
OXYCODONE AND ACETAMINOPHEN CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
OXYCODONE AND ASPIRIN CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
OXYCODONE AND ASPIRIN (HALF-STRENGTH) CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
OXYCODONE HYDROCHLORIDE AND ACETAMINOPHEN CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
OXYCODONE HYDROCHLORIDE AND IBUPROFEN CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
OXYCONTIN Comprehensive clinical and safety monograph for OXYCONTIN (OXYCONTIN).	Opioid Analgesic	caution
OXYMORPHONE HYDROCHLORIDE Comprehensive clinical and safety monograph for OXYMORPHONE HYDROCHLORIDE (OXYMORPHONE HYDROCHLORIDE).	Opioid Analgesic	caution
PALLADONE Comprehensive clinical and safety monograph for PALLADONE (PALLADONE).	Opioid Analgesic	caution
PAPA-DEINE #3 Comprehensive clinical and safety monograph for PAPA-DEINE #3 (PAPA-DEINE #3).	Opioid Analgesic Combination	caution
PAPA-DEINE #4 Comprehensive clinical and safety monograph for PAPA-DEINE #4 (PAPA-DEINE #4).	Opioid Analgesic Combination	caution
PENNTUSS Comprehensive clinical and safety monograph for PENNTUSS (PENNTUSS).	Opioid Antitussive	caution
PERCOCET Comprehensive clinical and safety monograph for PERCOCET (PERCOCET).	Opioid Analgesic Combination	caution
PERCODAN Comprehensive clinical and safety monograph for PERCODAN (PERCODAN).	Opioid Analgesic Combination	caution
PERCODAN-DEMI Comprehensive clinical and safety monograph for PERCODAN-DEMI (PERCODAN-DEMI).	Opioid Analgesic Combination	caution
PHENAPHEN W/ CODEINE NO. 2 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
PHENAPHEN W/ CODEINE NO. 3 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
PHENAPHEN W/ CODEINE NO. 4 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
PHENAPHEN-650 W/ CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
PHENERGAN VC W/ CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
PHENERGAN W/ CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
PHERAZINE VC W/ CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
PHERAZINE W/ CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
PHRENILIN WITH CAFFEINE AND CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
PIVYA Comprehensive clinical and safety monograph for PIVYA (PIVYA).	Opioid Partial Agonist	caution
PROBUPHINE Comprehensive clinical and safety monograph for PROBUPHINE (PROBUPHINE).	Opioid Partial Agonist	caution
PROMETH HYDROCHLORIDE,PHENYLEPHRINE HYDROCHLORIDE W/CODEINE PHOSPHATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
PROMETH VC W/ CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
PROPACET 100 Comprehensive clinical and safety monograph for PROPACET 100 (PROPACET 100).	Opioid analgesic combination	caution
PROPHENE 65 Comprehensive clinical and safety monograph for PROPHENE 65 (PROPHENE 65).	Opioid Analgesic	caution
PROPOXYPHENE COMPOUND 65 Comprehensive clinical and safety monograph for PROPOXYPHENE COMPOUND 65 (PROPOXYPHENE COMPOUND 65).	Opioid Analgesic Combination	caution
PROPOXYPHENE HYDROCHLORIDE Comprehensive clinical and safety monograph for PROPOXYPHENE HYDROCHLORIDE (PROPOXYPHENE HYDROCHLORIDE).	Opioid Analgesic	caution
PROPOXYPHENE HYDROCHLORIDE 65 Comprehensive clinical and safety monograph for PROPOXYPHENE HYDROCHLORIDE 65 (PROPOXYPHENE HYDROCHLORIDE 65).	Opioid Analgesic	caution
PROPOXYPHENE HYDROCHLORIDE AND ACETAMINOPHEN Comprehensive clinical and safety monograph for PROPOXYPHENE HYDROCHLORIDE AND ACETAMINOPHEN (PROPOXYPHENE HYDROCHLORIDE AND ACETAMINOPHEN).	Opioid Analgesic Combination	caution
Q-GESIC Comprehensive clinical and safety monograph for Q-GESIC (Q-GESIC).	Opioid Analgesic Combination	caution
QDOLO Comprehensive clinical and safety monograph for QDOLO (QDOLO).	Opioid Agonist	caution
QOLIANA Comprehensive clinical and safety monograph for QOLIANA (QOLIANA).	Opioid Agonist	caution
RELISTOR Comprehensive clinical and safety monograph for RELISTOR (RELISTOR).	Peripheral Opioid Antagonist	caution
REMIFENTANIL HYDROCHLORIDE Comprehensive clinical and safety monograph for REMIFENTANIL HYDROCHLORIDE (REMIFENTANIL HYDROCHLORIDE).	Opioid Anesthetic	caution
REPREXAIN Comprehensive clinical and safety monograph for REPREXAIN (REPREXAIN).	Opioid Combination Analgesic	caution
REVEX Comprehensive clinical and safety monograph for REVEX (REVEX).	Opioid Antagonist	caution
REVIA Comprehensive clinical and safety monograph for REVIA (REVIA).	Opioid Antagonist	caution
REXTOVY Comprehensive clinical and safety monograph for REXTOVY (REXTOVY).	Opioid Dependence Treatment	caution
ROXICET Comprehensive clinical and safety monograph for ROXICET (ROXICET).	Opioid Analgesic Combination	caution
ROXICET 5/500 Comprehensive clinical and safety monograph for ROXICET 5/500 (ROXICET 5/500).	Opioid Analgesic Combination	caution
ROXICODONE Comprehensive clinical and safety monograph for ROXICODONE (ROXICODONE).	Opioid Analgesic	caution
ROXILOX Comprehensive clinical and safety monograph for ROXILOX (ROXILOX).	Opioid Analgesic	caution
ROXIPRIN Comprehensive clinical and safety monograph for ROXIPRIN (ROXIPRIN).	Opioid Analgesic Combination	caution
ROXYBOND Comprehensive clinical and safety monograph for ROXYBOND (ROXYBOND).	Opioid Analgesic	caution
RYZOLT Comprehensive clinical and safety monograph for RYZOLT (RYZOLT).	Opioid Analgesic	caution
SOMA COMPOUND W/ CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
STADOL Comprehensive clinical and safety monograph for STADOL (STADOL).	Opioid Analgesic	caution
STADOL PRESERVATIVE FREE Comprehensive clinical and safety monograph for STADOL PRESERVATIVE FREE (STADOL PRESERVATIVE FREE).	Opioid Analgesic	caution
SUBLIMAZE PRESERVATIVE FREE Comprehensive clinical and safety monograph for SUBLIMAZE PRESERVATIVE FREE (SUBLIMAZE PRESERVATIVE FREE).	Opioid Analgesic	caution
SUBLOCADE Comprehensive clinical and safety monograph for SUBLOCADE (SUBLOCADE).	Partial Opioid Agonist	caution
SUBOXONE Comprehensive clinical and safety monograph for SUBOXONE (SUBOXONE).	Partial Opioid Agonist/Naloxone Combination	caution
SUBSYS Comprehensive clinical and safety monograph for SUBSYS (SUBSYS).	Opioid Analgesic	caution
SUBUTEX Comprehensive clinical and safety monograph for SUBUTEX (SUBUTEX).	Partial Opioid Agonist	caution
SUFENTA PRESERVATIVE FREE Comprehensive clinical and safety monograph for SUFENTA PRESERVATIVE FREE (SUFENTA PRESERVATIVE FREE).	Opioid Analgesic	caution
SUFENTANIL CITRATE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.	Opioid Agonist	avoid
SYMPROIC Comprehensive clinical and safety monograph for SYMPROIC (SYMPROIC).	Opioid Antagonist (PAMORA)	caution
SYNALGOS-DC Comprehensive clinical and safety monograph for SYNALGOS-DC (SYNALGOS-DC).	Opioid Analgesic	caution
SYNALGOS-DC-A Comprehensive clinical and safety monograph for SYNALGOS-DC-A (SYNALGOS-DC-A).	Opioid Analgesic	caution
TALACEN Comprehensive clinical and safety monograph for TALACEN (TALACEN).	Opioid analgesic	caution
TALWIN Comprehensive clinical and safety monograph for TALWIN (TALWIN).	Opioid Analgesic	caution
TALWIN 50 Comprehensive clinical and safety monograph for TALWIN 50 (TALWIN 50).	Opioid Analgesic	caution
TALWIN COMPOUND Comprehensive clinical and safety monograph for TALWIN COMPOUND (TALWIN COMPOUND).	Opioid Analgesic Combination	caution
TALWIN NX Comprehensive clinical and safety monograph for TALWIN NX (TALWIN NX).	Opioid Partial Agonist/Antagonist	caution
TAPENTADOL CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs can cause serotonin syndrome.	Opioid Agonist	safe
TAPENTADOL HYDROCHLORIDE CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs can cause serotonin syndrome.	Opioid Agonist	safe
TARGINIQ Comprehensive clinical and safety monograph for TARGINIQ (TARGINIQ).	Opioid Analgesic Combination	caution
TRAL Comprehensive clinical and safety monograph for TRAL (TRAL).	Opioid Analgesic	caution
Tramadol Avoid in pregnancy. Tramadol is a synthetic opioid and norepinephrine-serotonin reuptake inhibitor. Associated with Neonatal Opioid Withdrawal Syndrome (NOWS) and neonatal seizures when used near delivery. Contraindicated during breastfeeding (FDA 2017, same warning as codeine). No established teratogenicity at therapeutic doses but risk-benefit strongly favors alternatives.	Opioid Agonist	avoid
TRAMADOL HYDROCHLORIDE CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs and other serotonergic drugs can cause serotonin syndrome.	Opioid Agonist	avoid
TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs and other serotonergic drugs can cause serotonin syndrome.	Opioid Agonist	avoid
TROXYCA ER Comprehensive clinical and safety monograph for TROXYCA ER (TROXYCA ER).	Opioid Analgesic (with abuse-deterrent properties)	caution
TUSSICAPS Comprehensive clinical and safety monograph for TUSSICAPS (TUSSICAPS).	Opioid Antitussive-Expectorant Combination	caution
TUSSIGON Comprehensive clinical and safety monograph for TUSSIGON (TUSSIGON).	Opioid antitussive	caution
TUSSIONEX PENNKINETIC Comprehensive clinical and safety monograph for TUSSIONEX PENNKINETIC (TUSSIONEX PENNKINETIC).	Opioid antitussive	caution
TYCOLET Comprehensive clinical and safety monograph for TYCOLET (TYCOLET).	Opioid analgesic combination	caution
TYLENOL Comprehensive clinical and safety monograph for TYLENOL (TYLENOL).	Analgesic (non-opioid)	caution
TYLENOL W/ CODEINE CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
TYLENOL W/ CODEINE NO. 1 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
TYLENOL W/ CODEINE NO. 2 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
TYLENOL W/ CODEINE NO. 3 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
TYLENOL W/ CODEINE NO. 4 CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.	Opioid Agonist	avoid
TYLOX Comprehensive clinical and safety monograph for TYLOX (TYLOX).	Opioid analgesic combination	caution
TYLOX-325 Comprehensive clinical and safety monograph for TYLOX-325 (TYLOX-325).	Opioid analgesic combination	caution
TYMTRAN Comprehensive clinical and safety monograph for TYMTRAN (TYMTRAN).	Opioid analgesic combination	caution
ULTIVA Comprehensive clinical and safety monograph for ULTIVA (ULTIVA).	Opioid Analgesic	caution
ULTRACET Comprehensive clinical and safety monograph for ULTRACET (ULTRACET).	Opioid Analgesic Combination	caution
ULTRAM Comprehensive clinical and safety monograph for ULTRAM (ULTRAM).	Opioid Analgesic	caution
ULTRAM ER Comprehensive clinical and safety monograph for ULTRAM ER (ULTRAM ER).	Opioid Analgesic	caution
VICODIN Comprehensive clinical and safety monograph for VICODIN (VICODIN).	Opioid Analgesic	caution
VICODIN ES Comprehensive clinical and safety monograph for VICODIN ES (VICODIN ES).	Opioid Analgesic	caution
VICODIN HP Comprehensive clinical and safety monograph for VICODIN HP (VICODIN HP).	Opioid Analgesic	caution
VICOPRIN Comprehensive clinical and safety monograph for VICOPRIN (VICOPRIN).	Opioid Analgesic	caution
VICOPROFEN Comprehensive clinical and safety monograph for VICOPROFEN (VICOPROFEN).	Opioid Analgesic Combination	caution
VIVITROL Comprehensive clinical and safety monograph for VIVITROL (VIVITROL).	Opioid Antagonist	caution
WESTADONE Comprehensive clinical and safety monograph for WESTADONE (WESTADONE).	Opioid Agonist	caution
WYGESIC Comprehensive clinical and safety monograph for WYGESIC (WYGESIC).	Opioid Analgesic Combination	caution
XARTEMIS XR Comprehensive clinical and safety monograph for XARTEMIS XR (XARTEMIS XR).	Opioid Analgesic	caution
XTAMPZA ER Comprehensive clinical and safety monograph for XTAMPZA ER (XTAMPZA ER).	Opioid Analgesic	caution
ZIMHI Comprehensive clinical and safety monograph for ZIMHI (ZIMHI).	Opioid Antagonist	caution
ZIPAN-25 Comprehensive clinical and safety monograph for ZIPAN-25 (ZIPAN-25).	Opioid Analgesic	caution
ZIPAN-50 Comprehensive clinical and safety monograph for ZIPAN-50 (ZIPAN-50).	Opioid Analgesic	caution
ZOHYDRO ER Comprehensive clinical and safety monograph for ZOHYDRO ER (ZOHYDRO ER).	Opioid Analgesic	caution
ZUBSOLV Comprehensive clinical and safety monograph for ZUBSOLV (ZUBSOLV).	Opioid Partial Agonist	caution
ZYDONE Comprehensive clinical and safety monograph for ZYDONE (ZYDONE).	Opioid Analgesic	caution

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.