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Registry Hub

Therapeutic Classification

opioid agonist Registry

Clinical reference for opioid agonist medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (opioid agonist)

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.

MedicationTherapeutic ClassMaternal Safety

ACETAMINOPHEN AND CODEINE PHOSPHATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

ACETAMINOPHEN AND HYDROCODONE BITARTRATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

ACETAMINOPHEN AND PENTAZOCINE HYDROCHLORIDE

CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.

Opioid Agonist-Antagonist

safe

ACETAMINOPHEN, ASPIRIN, AND CODEINE PHOSPHATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

ACETAMINOPHEN, CAFFEINE AND DIHYDROCODEINE BITARTRATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

ACETAMINOPHEN; OXYCODONE HYDROCHLORIDE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

ACTIFED W/ CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

APOMORPHINE HYDROCHLORIDE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

BUTALBITAL, ASPIRIN, CAFFEINE, AND CODEINE PHOSPHATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

CAPITAL AND CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

CARISOPRODOL, ASPIRIN AND CODEINE PHOSPHATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

Codeine

Avoid. Codeine is a prodrug converted by CYP2D6 to morphine. Ultra-rapid metabolizers produce excessive morphine, posing risk of neonatal opioid toxicity. In 2017, the FDA contraindicated codeine (and tramadol) for breastfeeding mothers due to neonatal deaths from morphine toxicity in infants of ultra-rapid metabolizers. In pregnancy, opioids carry risk of Neonatal Opioid Withdrawal Syndrome (NOWS), fetal growth restriction, and preterm birth with chronic use. For acute pain in pregnancy, acetaminophen is preferred. Short-term use of codeine near term poses additional risk of neonatal respiratory depression.

Opioid Agonist

avoid

CODEINE SULFATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

CODEINE, ASPIRIN, APAP FORMULA NO. 2

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

CODEINE, ASPIRIN, APAP FORMULA NO. 3

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

CODEINE, ASPIRIN, APAP FORMULA NO. 4

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

EMPRACET W/ CODEINE PHOSPHATE #3

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

EMPRACET W/ CODEINE PHOSPHATE #4

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

FENTANYL

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FENTANYL CITRATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FENTANYL CITRATE AND DROPERIDOL

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FENTANYL CITRATE PRESERVATIVE FREE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FENTANYL-100

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FENTANYL-12

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FENTANYL-25

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FENTANYL-37

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FENTANYL-50

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FENTANYL-62

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FENTANYL-75

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FENTANYL-87

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

FIORICET W/ CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

FIORINAL W/CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

HYDROCODONE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

HYDROCODONE BITARTRATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

HYDROCODONE BITARTRATE AND ACETAMINOPHEN

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

HYDROCODONE BITARTRATE AND ASPIRIN

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

HYDROCODONE BITARTRATE AND CHLORPHENIRAMINE MALEATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

HYDROCODONE BITARTRATE AND HOMATROPINE METHYLBROMIDE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

HYDROCODONE POLISTIREX AND CHLORPHENIRAMINE POLISTIREX

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

HYDROCODONE POLISTIREX AND CHLORPHENIRAMNE POLISTIREX

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

HYDROMORPHONE HYDROCHLORIDE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

MEPERIDINE AND ATROPINE SULFATE

MAOIs can cause serotonin syndrome and hyperpyrexia Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

MEPERIDINE HYDROCHLORIDE

MAOIs can cause serotonin syndrome and hyperpyrexia Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE

MAOIs can cause serotonin syndrome and hyperpyrexia Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

Methadone (MOUD)

Standard-of-care MOUD for opioid use disorder in pregnancy. Methadone maintenance therapy reduces illicit drug use, stabilizes maternal physiology, and improves prenatal care engagement and fetal outcomes. Longer-established than buprenorphine in pregnancy with extensive outcome data. Requires daily observed dosing at an opioid treatment program (OTP). Associated with more severe and longer NOWS than buprenorphine. Dose changes required throughout pregnancy due to altered pharmacokinetics. Not the same as analgesic methadone use.

Opioid Agonist

safe

METHADONE HYDROCHLORIDE

CYP450 inducers or inhibitors can significantly alter levels Can cause QT prolongation and life-threatening respiratory depression.

Opioid Agonist

avoid

METHADONE HYDROCHLORIDE INTENSOL

CYP450 inducers or inhibitors can significantly alter levels Can cause QT prolongation and life-threatening respiratory depression.

Opioid Agonist

avoid

METHADOSE

Comprehensive clinical and safety monograph for METHADOSE (METHADOSE).

Opioid Agonist

caution

MORPHINE SULFATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

MORPHINE SULFATE (AUTOINJECTOR)

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

NALBUPHINE

CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.

Opioid Agonist-Antagonist

safe

NALBUPHINE HYDROCHLORIDE

CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.

Opioid Agonist-Antagonist

safe

NALOXONE HYDROCHLORIDE AND PENTAZOCINE HYDROCHLORIDE

CNS depressants may enhance sedative effects Can cause withdrawal in patients dependent on other opioids.

Opioid Agonist-Antagonist

safe

ORLAAM

Comprehensive clinical and safety monograph for ORLAAM (ORLAAM).

Opioid agonist

caution

OXYCODONE 2.5/APAP 500

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

OXYCODONE 5/APAP 500

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

OXYCODONE AND ACETAMINOPHEN

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

OXYCODONE AND ASPIRIN

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

OXYCODONE AND ASPIRIN (HALF-STRENGTH)

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

OXYCODONE HYDROCHLORIDE AND ACETAMINOPHEN

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

OXYCODONE HYDROCHLORIDE AND IBUPROFEN

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

PHENAPHEN W/ CODEINE NO. 2

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

PHENAPHEN W/ CODEINE NO. 3

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

PHENAPHEN W/ CODEINE NO. 4

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

PHENAPHEN-650 W/ CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

PHENERGAN VC W/ CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

PHENERGAN W/ CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

PHERAZINE VC W/ CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

PHERAZINE W/ CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

PHRENILIN WITH CAFFEINE AND CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

PROMETH HYDROCHLORIDE,PHENYLEPHRINE HYDROCHLORIDE W/CODEINE PHOSPHATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

PROMETH VC W/ CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

QDOLO

Comprehensive clinical and safety monograph for QDOLO (QDOLO).

Opioid Agonist

caution

QOLIANA

Comprehensive clinical and safety monograph for QOLIANA (QOLIANA).

Opioid Agonist

caution

SOMA COMPOUND W/ CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

SUBLOCADE

Comprehensive clinical and safety monograph for SUBLOCADE (SUBLOCADE).

Partial Opioid Agonist

caution

SUBOXONE

Comprehensive clinical and safety monograph for SUBOXONE (SUBOXONE).

Partial Opioid Agonist/Naloxone Combination

caution

SUBUTEX

Comprehensive clinical and safety monograph for SUBUTEX (SUBUTEX).

Partial Opioid Agonist

caution

SUFENTANIL CITRATE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur.

Opioid Agonist

avoid

TAPENTADOL

CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs can cause serotonin syndrome.

Opioid Agonist

safe

TAPENTADOL HYDROCHLORIDE

CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs can cause serotonin syndrome.

Opioid Agonist

safe

Tramadol

Avoid in pregnancy. Tramadol is a synthetic opioid and norepinephrine-serotonin reuptake inhibitor. Associated with Neonatal Opioid Withdrawal Syndrome (NOWS) and neonatal seizures when used near delivery. Contraindicated during breastfeeding (FDA 2017, same warning as codeine). No established teratogenicity at therapeutic doses but risk-benefit strongly favors alternatives.

Opioid Agonist

avoid

TRAMADOL HYDROCHLORIDE

CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs and other serotonergic drugs can cause serotonin syndrome.

Opioid Agonist

avoid

TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN

CNS depressants including alcohol and benzodiazepines increase sedation risk MAOIs and other serotonergic drugs can cause serotonin syndrome.

Opioid Agonist

avoid

TYLENOL W/ CODEINE

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

TYLENOL W/ CODEINE NO. 1

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

TYLENOL W/ CODEINE NO. 2

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

TYLENOL W/ CODEINE NO. 3

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

TYLENOL W/ CODEINE NO. 4

CNS depressants including alcohol and benzodiazepines increase sedation risk Life-threatening respiratory depression may occur especially in CYP2D6 ultra-rapid metabolizers.

Opioid Agonist

avoid

WESTADONE

Comprehensive clinical and safety monograph for WESTADONE (WESTADONE).

Opioid Agonist

caution