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Clinical Notice:OpiCalc is not a substitute for professional clinical judgment. Always verify dosages and guidelines.

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Registry Hub

Therapeutic Classification

penicillin antibiotic Registry

Clinical reference for penicillin antibiotic medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (penicillin antibiotic)

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.

MedicationTherapeutic ClassMaternal Safety

AMCILL

Comprehensive clinical and safety monograph for AMCILL (AMCILL).

Penicillin Antibiotic

caution

AMOXICILLIN

Probenecid decreases renal tubular secretion of amoxicillin May reduce efficacy of oral contraceptives Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

AMOXICILLIN AND CLAVULANATE POTASSIUM

Probenecid decreases renal tubular secretion of amoxicillin May reduce efficacy of oral contraceptives Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

AMOXICILLIN PEDIATRIC

Probenecid decreases renal tubular secretion of amoxicillin May reduce efficacy of oral contraceptives Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

Amoxicillin-Clavulanate

Amoxicillin-clavulanate is a broad-spectrum oral antibiotic combining a penicillin with a beta-lactamase inhibitor. It is generally considered safe in pregnancy for standard indications such as urinary tract infections, skin and soft tissue infections, and community-acquired respiratory infections. However, the landmark ORACLE I randomised controlled trial (Kenyon et al., Lancet 2001) demonstrated a statistically significant increase in necrotising enterocolitis (NEC) in neonates born to mothers who received co-amoxiclav for preterm prelabour rupture of membranes (PPROM). Consequently, erythromycin (or azithromycin) is the preferred antibiotic for PPROM latency therapy. Outside the PPROM context, the overall risk-benefit profile remains favourable in pregnancy.

Penicillin Antibiotic + Beta-Lactamase Inhibitor

caution

AMOXIL

Comprehensive clinical and safety monograph for AMOXIL (AMOXIL).

Penicillin Antibiotic

caution

Ampicillin

Ampicillin is a broad-spectrum aminopenicillin antibiotic with an established safety record across all trimesters of pregnancy. It is the first-line intravenous agent for Group B Streptococcus (GBS) intrapartum prophylaxis per CDC and ACOG guidelines, the drug of choice (in combination with gentamicin) for treatment of listeriosis in pregnancy, and a standard agent for urinary tract infections, chorioamnionitis regimens, and endocarditis prophylaxis in obstetric patients. No teratogenic signal has been identified in large epidemiological cohorts. It does not carry the necrotising enterocolitis (NEC) risk associated with amoxicillin-clavulanate in PPROM. Oral bioavailability is limited and erratic; the IV/IM route is standard for serious obstetric indications.

Penicillin Antibiotic

safe

AMPICILLIN AND SULBACTAM

Probenecid decreases renal tubular secretion of ampicillin Allopurinol may increase the incidence of skin rashes Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

AMPICILLIN SODIUM

Probenecid decreases renal tubular secretion of ampicillin Allopurinol may increase the incidence of skin rashes Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

AMPICILLIN TRIHYDRATE

Probenecid decreases renal tubular secretion of ampicillin Allopurinol may increase the incidence of skin rashes Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

AUGMENTIN '125'

Comprehensive clinical and safety monograph for AUGMENTIN '125' (AUGMENTIN '125').

Penicillin Antibiotic

caution

AUGMENTIN '200'

Comprehensive clinical and safety monograph for AUGMENTIN '200' (AUGMENTIN '200').

Penicillin Antibiotic

caution

AUGMENTIN '250'

Comprehensive clinical and safety monograph for AUGMENTIN '250' (AUGMENTIN '250').

Penicillin Antibiotic

caution

AUGMENTIN '400'

Comprehensive clinical and safety monograph for AUGMENTIN '400' (AUGMENTIN '400').

Penicillin Antibiotic

caution

AUGMENTIN '500'

Comprehensive clinical and safety monograph for AUGMENTIN '500' (AUGMENTIN '500').

Penicillin Antibiotic

caution

AUGMENTIN '875'

Comprehensive clinical and safety monograph for AUGMENTIN '875' (AUGMENTIN '875').

Penicillin Antibiotic

caution

AUGMENTIN ES-600

Comprehensive clinical and safety monograph for AUGMENTIN ES-600 (AUGMENTIN ES-600).

Penicillin Antibiotic

caution

AUGMENTIN XR

Comprehensive clinical and safety monograph for AUGMENTIN XR (AUGMENTIN XR).

Penicillin Antibiotic

caution

AZLIN

Comprehensive clinical and safety monograph for AZLIN (AZLIN).

Penicillin Antibiotic

caution

BACTOCILL

Comprehensive clinical and safety monograph for BACTOCILL (BACTOCILL).

Penicillin Antibiotic

caution

BACTOCILL IN PLASTIC CONTAINER

Comprehensive clinical and safety monograph for BACTOCILL IN PLASTIC CONTAINER (BACTOCILL IN PLASTIC CONTAINER).

Penicillin Antibiotic

caution

BEEPEN-VK

Comprehensive clinical and safety monograph for BEEPEN-VK (BEEPEN-VK).

Penicillin Antibiotic

caution

BETAPEN-VK

Comprehensive clinical and safety monograph for BETAPEN-VK (BETAPEN-VK).

Penicillin Antibiotic

caution

BICILLIN

Comprehensive clinical and safety monograph for BICILLIN (BICILLIN).

Penicillin Antibiotic

caution

BICILLIN C-R

Comprehensive clinical and safety monograph for BICILLIN C-R (BICILLIN C-R).

Penicillin Antibiotic

caution

BICILLIN C-R 900/300

Comprehensive clinical and safety monograph for BICILLIN C-R 900/300 (BICILLIN C-R 900/300).

Penicillin Antibiotic

caution

BICILLIN L-A

Comprehensive clinical and safety monograph for BICILLIN L-A (BICILLIN L-A).

Penicillin Antibiotic

caution

CLOXACILLIN SODIUM

Probenecid may decrease excretion Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

CLOXAPEN

Comprehensive clinical and safety monograph for CLOXAPEN (CLOXAPEN).

Penicillin Antibiotic

caution

CYCLAPEN-W

Comprehensive clinical and safety monograph for CYCLAPEN-W (CYCLAPEN-W).

Penicillin Antibiotic

caution

DICLOXACILLIN SODIUM

Probenecid may decrease excretion Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

DISPERMOX

Comprehensive clinical and safety monograph for DISPERMOX (DISPERMOX).

Penicillin Antibiotic

caution

DURACILLIN A.S.

Comprehensive clinical and safety monograph for DURACILLIN A.S. (DURACILLIN A.S.).

Penicillin Antibiotic

caution

DYCILL

Comprehensive clinical and safety monograph for DYCILL (DYCILL).

Penicillin Antibiotic

caution

DYNAPEN

Comprehensive clinical and safety monograph for DYNAPEN (DYNAPEN).

Penicillin Antibiotic

caution

GEOCILLIN

Comprehensive clinical and safety monograph for GEOCILLIN (GEOCILLIN).

Penicillin Antibiotic

caution

GEOPEN

Comprehensive clinical and safety monograph for GEOPEN (GEOPEN).

Penicillin Antibiotic

caution

KLEBCIL

Comprehensive clinical and safety monograph for KLEBCIL (KLEBCIL).

Penicillin Antibiotic

caution

LAROTID

Comprehensive clinical and safety monograph for LAROTID (LAROTID).

Penicillin Antibiotic

caution

LEDERCILLIN VK

Comprehensive clinical and safety monograph for LEDERCILLIN VK (LEDERCILLIN VK).

Penicillin Antibiotic

caution

NAFCILLIN SODIUM

Warfarin metabolism is increased decreasing INR Can cause vein irritation and phlebitis with IV administration.

Penicillin Antibiotic

safe

NALLPEN

Comprehensive clinical and safety monograph for NALLPEN (NALLPEN).

Penicillin Antibiotic

caution

NALLPEN IN PLASTIC CONTAINER

Comprehensive clinical and safety monograph for NALLPEN IN PLASTIC CONTAINER (NALLPEN IN PLASTIC CONTAINER).

Penicillin Antibiotic

caution

OMNIPEN (AMPICILLIN)

Probenecid decreases renal tubular secretion of ampicillin Allopurinol may increase the incidence of skin rashes Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

OMNIPEN-N

Comprehensive clinical and safety monograph for OMNIPEN-N (OMNIPEN-N).

Penicillin Antibiotic

caution

OXACILLIN SODIUM

Probenecid may decrease excretion Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

PEN-VEE K

Comprehensive clinical and safety monograph for PEN-VEE K (PEN-VEE K).

Penicillin Antibiotic

caution

PENAPAR-VK

Comprehensive clinical and safety monograph for PENAPAR-VK (PENAPAR-VK).

Penicillin Antibiotic

caution

PENBRITIN

Comprehensive clinical and safety monograph for PENBRITIN (PENBRITIN).

Penicillin Antibiotic

caution

PENBRITIN-S

Comprehensive clinical and safety monograph for PENBRITIN-S (PENBRITIN-S).

Penicillin Antibiotic

caution

PENICILLIN

Comprehensive clinical and safety monograph for PENICILLIN (PENICILLIN).

Penicillin Antibiotic

caution

PENICILLIN G POTASSIUM

Probenecid may decrease excretion Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

PENICILLIN G POTASSIUM IN PLASTIC CONTAINER

Probenecid may decrease excretion Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

PENICILLIN G PROCAINE

Probenecid may decrease excretion Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

PENICILLIN G SODIUM

Probenecid may decrease excretion Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

PENICILLIN V POTASSIUM

Probenecid may decrease excretion Serious and occasionally fatal hypersensitivity reactions have been reported.

Penicillin Antibiotic

safe

PENICILLIN-2

Comprehensive clinical and safety monograph for PENICILLIN-2 (PENICILLIN-2).

Penicillin Antibiotic

caution

PENICILLIN-VK

Comprehensive clinical and safety monograph for PENICILLIN-VK (PENICILLIN-VK).

Penicillin Antibiotic

caution

PENTIDS '200'

Comprehensive clinical and safety monograph for PENTIDS '200' (PENTIDS '200').

Penicillin Antibiotic

caution

PENTIDS '250'

Comprehensive clinical and safety monograph for PENTIDS '250' (PENTIDS '250').

Penicillin Antibiotic

caution

PENTIDS '400'

Comprehensive clinical and safety monograph for PENTIDS '400' (PENTIDS '400').

Penicillin Antibiotic

caution

PENTIDS '800'

Comprehensive clinical and safety monograph for PENTIDS '800' (PENTIDS '800').

Penicillin Antibiotic

caution

PERMAPEN

Comprehensive clinical and safety monograph for PERMAPEN (PERMAPEN).

Penicillin antibiotic

caution

PFIZERPEN

Comprehensive clinical and safety monograph for PFIZERPEN (PFIZERPEN).

Penicillin antibiotic

caution

PIPERACILLIN

Comprehensive clinical and safety monograph for PIPERACILLIN (PIPERACILLIN).

Penicillin Antibiotic

caution

PIPERACILLIN AND TAZOBACTAM

Comprehensive clinical and safety monograph for PIPERACILLIN AND TAZOBACTAM (PIPERACILLIN AND TAZOBACTAM).

Penicillin Antibiotic / Beta-Lactamase Inhibitor Combination

caution

Piperacillin-Tazobactam

Broad-spectrum beta-lactam/beta-lactamase inhibitor combination used IV for polymicrobial serious infections in pregnancy including chorioamnionitis, complicated UTI/pyelonephritis, and postpartum endometritis. No evidence of teratogenicity. Commonly used in obstetric practice for serious infections requiring broad coverage.

Penicillin Antibiotic + Beta-Lactamase Inhibitor

safe

PIPRACIL

Comprehensive clinical and safety monograph for PIPRACIL (PIPRACIL).

Penicillin Antibiotic

caution

POLYCILLIN

Comprehensive clinical and safety monograph for POLYCILLIN (POLYCILLIN).

Penicillin Antibiotic

caution

POLYCILLIN-N

Comprehensive clinical and safety monograph for POLYCILLIN-N (POLYCILLIN-N).

Penicillin Antibiotic

caution

POLYCILLIN-PRB

Comprehensive clinical and safety monograph for POLYCILLIN-PRB (POLYCILLIN-PRB).

Penicillin Antibiotic

caution

POLYMOX

Comprehensive clinical and safety monograph for POLYMOX (POLYMOX).

Penicillin Antibiotic

caution

PRINCIPEN

Comprehensive clinical and safety monograph for PRINCIPEN (PRINCIPEN).

Aminopenicillin Antibiotic

caution

PRINCIPEN '125'

Comprehensive clinical and safety monograph for PRINCIPEN '125' (PRINCIPEN '125').

Aminopenicillin Antibiotic

caution

PRINCIPEN '250'

Comprehensive clinical and safety monograph for PRINCIPEN '250' (PRINCIPEN '250').

Aminopenicillin Antibiotic

caution

PRINCIPEN '500'

Comprehensive clinical and safety monograph for PRINCIPEN '500' (PRINCIPEN '500').

Aminopenicillin Antibiotic

caution

PROBAMPACIN

Comprehensive clinical and safety monograph for PROBAMPACIN (PROBAMPACIN).

Penicillin Antibiotic

caution

PROSTAPHLIN

Comprehensive clinical and safety monograph for PROSTAPHLIN (PROSTAPHLIN).

Penicillin Antibiotic

caution

PYOPEN

Comprehensive clinical and safety monograph for PYOPEN (PYOPEN).

Penicillin Antibiotic

caution

SPECTROBID

Comprehensive clinical and safety monograph for SPECTROBID (SPECTROBID).

Penicillin Antibiotic

caution

STAPHCILLIN

Comprehensive clinical and safety monograph for STAPHCILLIN (STAPHCILLIN).

Penicillin Antibiotic

caution

TEGOPEN

Comprehensive clinical and safety monograph for TEGOPEN (TEGOPEN).

Penicillin antibiotic

caution

TOTACILLIN

Comprehensive clinical and safety monograph for TOTACILLIN (TOTACILLIN).

Penicillin Antibiotic

caution

TRIMOX

Comprehensive clinical and safety monograph for TRIMOX (TRIMOX).

Penicillin Antibiotic

caution

UNASYN

Comprehensive clinical and safety monograph for UNASYN (UNASYN).

Penicillin Antibiotic

caution

UNIPEN

Comprehensive clinical and safety monograph for UNIPEN (UNIPEN).

Penicillin Antibiotic

caution

UNIPEN IN PLASTIC CONTAINER

Comprehensive clinical and safety monograph for UNIPEN IN PLASTIC CONTAINER (UNIPEN IN PLASTIC CONTAINER).

Penicillin Antibiotic

caution

UTICILLIN VK

Comprehensive clinical and safety monograph for UTICILLIN VK (UTICILLIN VK).

Penicillin Antibiotic

caution

UTIMOX

Comprehensive clinical and safety monograph for UTIMOX (UTIMOX).

Penicillin Antibiotic

caution

V-CILLIN

Comprehensive clinical and safety monograph for V-CILLIN (V-CILLIN).

Penicillin Antibiotic

caution

V-CILLIN K

Comprehensive clinical and safety monograph for V-CILLIN K (V-CILLIN K).

Penicillin Antibiotic

caution

VEETIDS

Comprehensive clinical and safety monograph for VEETIDS (VEETIDS).

Penicillin Antibiotic

caution

VEETIDS '125'

Comprehensive clinical and safety monograph for VEETIDS '125' (VEETIDS '125').

Penicillin Antibiotic

caution

VEETIDS '250'

Comprehensive clinical and safety monograph for VEETIDS '250' (VEETIDS '250').

Penicillin Antibiotic

caution

VEETIDS '500'

Comprehensive clinical and safety monograph for VEETIDS '500' (VEETIDS '500').

Penicillin Antibiotic

caution

VERSAPEN

Comprehensive clinical and safety monograph for VERSAPEN (VERSAPEN).

Penicillin Antibiotic

caution

VERSAPEN-K

Comprehensive clinical and safety monograph for VERSAPEN-K (VERSAPEN-K).

Penicillin Antibiotic

caution

WYMOX

Comprehensive clinical and safety monograph for WYMOX (WYMOX).

Penicillin Antibiotic

caution