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Registry Hub

Therapeutic Classification

typical antipsychotic Registry

Clinical reference for typical antipsychotic medications. Access safety monographs, dosing adjustments, and drug-drug interactions for all registered brand names and generics in this class.

Registered Medications (typical antipsychotic)

This therapeutic registry is dynamically synthesized from professional clinical sources. Listing of a medication does not imply equivalence; refer to individual monographs for head-to-head pharmacological data.

MedicationTherapeutic ClassMaternal Safety

ABILIFY

There are no adequate and well-controlled studies in pregnant women. Use only if potential benefit justifies potential risk to the fetus.

Atypical antipsychotic

caution

ABILIFY ASIMTUFII

Pregnancy Category C: Aripiprazole crosses the placenta and may cause extrapyramidal symptoms or withdrawal in neonates. Use only if potential benefit justifies risk to the fetus.

Atypical antipsychotic

caution

ABILIFY MAINTENA KIT

Use during pregnancy only if potential benefit justifies potential risk to fetus; may cause extrapyramidal and/or withdrawal symptoms in neonates.

Atypical antipsychotic

caution

ABILIFY MYCITE KIT

Comprehensive clinical and safety monograph for ABILIFY MYCITE KIT (ABILIFY MYCITE KIT).

Atypical antipsychotic

caution

ARIPIPRAZOLE

Strong CYP3A4 inhibitors (eg ketoconazole) or inducers (eg carbamazepine) require dose adjustment May cause suicidal thoughts and metabolic changes including weight gain and dyslipidemia.

Atypical Antipsychotic

safe

ARISTADA

Comprehensive clinical and safety monograph for ARISTADA (ARISTADA).

Atypical Antipsychotic

caution

ARISTADA INITIO KIT

Comprehensive clinical and safety monograph for ARISTADA INITIO KIT (ARISTADA INITIO KIT).

Atypical Antipsychotic

caution

ASENAPINE MALEATE

Strong CYP1A2 inhibitors like fluvoxamine increase asenapine levels Sublingual administration food and drink can decrease absorption May cause cerebrovascular events in elderly patients with dementia.

Atypical Antipsychotic

safe

BREXPIPRAZOLE

Strong CYP3A4 or CYP2D6 inhibitors require dose adjustment May cause suicidal thoughts and metabolic changes including weight gain and dyslipidemia.

Atypical Antipsychotic

safe

CAPLYTA

Comprehensive clinical and safety monograph for CAPLYTA (CAPLYTA).

Atypical Antipsychotic

caution

CARIPRAZINE HYDROCHLORIDE

Comprehensive clinical and safety monograph for CARIPRAZINE HYDROCHLORIDE (CARIPRAZINE HYDROCHLORIDE).

Atypical Antipsychotic

caution

CLOZAPINE

Bone marrow suppressants may increase risk of agranulocytosis Can cause severe neutropenia and agranulocytosis requiring mandatory WBC monitoring.

Atypical Antipsychotic

safe

CLOZARIL

Comprehensive clinical and safety monograph for CLOZARIL (CLOZARIL).

Atypical Antipsychotic

caution

DAPIPRAZOLE HYDROCHLORIDE

Comprehensive clinical and safety monograph for DAPIPRAZOLE HYDROCHLORIDE (DAPIPRAZOLE HYDROCHLORIDE).

Atypical Antipsychotic

caution

FANAPT

Comprehensive clinical and safety monograph for FANAPT (FANAPT).

Atypical Antipsychotic

caution

FAZACLO ODT

Comprehensive clinical and safety monograph for FAZACLO ODT (FAZACLO ODT).

Atypical Antipsychotic

caution

FLUPHENAZINE

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and neuroleptic malignant syndrome.

Typical Antipsychotic

safe

FLUPHENAZINE DECANOATE

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and neuroleptic malignant syndrome.

Typical Antipsychotic

safe

FLUPHENAZINE HCL

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and neuroleptic malignant syndrome.

Typical Antipsychotic

safe

FLUPHENAZINE HYDROCHLORIDE

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and neuroleptic malignant syndrome.

Typical Antipsychotic

safe

GEODON

Comprehensive clinical and safety monograph for GEODON (GEODON).

Atypical Antipsychotic

caution

HALOPERIDOL DECANOATE

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and QT prolongation.

Typical Antipsychotic

safe

HALOPERIDOL INTENSOL

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and QT prolongation.

Typical Antipsychotic

safe

HALOPERIDOL LACTATE

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and QT prolongation.

Typical Antipsychotic

safe

ILOPERIDONE

Strong CYP2D6 or CYP3A4 inhibitors require dose adjustment Can cause orthostatic hypotension and QT prolongation.

Atypical Antipsychotic

safe

INVEGA

Comprehensive clinical and safety monograph for INVEGA (INVEGA).

Atypical Antipsychotic

caution

INVEGA HAFYERA

Comprehensive clinical and safety monograph for INVEGA HAFYERA (INVEGA HAFYERA).

Atypical Antipsychotic

caution

INVEGA SUSTENNA

Comprehensive clinical and safety monograph for INVEGA SUSTENNA (INVEGA SUSTENNA).

Atypical Antipsychotic

caution

INVEGA TRINZA

Comprehensive clinical and safety monograph for INVEGA TRINZA (INVEGA TRINZA).

Atypical Antipsychotic

caution

LATUDA

Comprehensive clinical and safety monograph for LATUDA (LATUDA).

Atypical Antipsychotic

caution

LUMATEPERONE

Comprehensive clinical and safety monograph for LUMATEPERONE (LUMATEPERONE).

Atypical Antipsychotic

caution

LUMATEPERONE TOSYLATE

Comprehensive clinical and safety monograph for LUMATEPERONE TOSYLATE (LUMATEPERONE TOSYLATE).

Atypical Antipsychotic

caution

LURASIDONE HYDROCHLORIDE

Strong CYP3A4 inhibitors and inducers are contraindicated Can cause somnolence and akathisia.

Atypical Antipsychotic

safe

LYBALVI

Comprehensive clinical and safety monograph for LYBALVI (LYBALVI).

Atypical Antipsychotic

caution

NUPLAZID

Comprehensive clinical and safety monograph for NUPLAZID (NUPLAZID).

Atypical Antipsychotic

caution

OLANZAPINE AND FLUOXETINE HYDROCHLORIDE

CNS depressants may enhance sedative effects Can cause metabolic changes including weight gain hyperlipidemia and hyperglycemia.

Atypical Antipsychotic

safe

PALIPERIDONE

Strong CYP3A4 or P-gp inducers may decrease levels Can cause QT prolongation and orthostatic hypotension.

Atypical Antipsychotic

safe

PALIPERIDONE PALMITATE

Strong CYP3A4 or P-gp inducers may decrease levels Can cause QT prolongation and orthostatic hypotension.

Atypical Antipsychotic

safe

PERPHENAZINE

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and neuroleptic malignant syndrome.

Typical Antipsychotic

safe

PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDE

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and neuroleptic malignant syndrome.

Typical Antipsychotic

safe

PIMOZIDE

Strong CYP3A4 inhibitors are contraindicated due to risk of QT prolongation Can cause QT prolongation and extrapyramidal symptoms.

Typical Antipsychotic

safe

PROCHLORPERAZINE

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and neuroleptic malignant syndrome.

Typical Antipsychotic / Antiemetic

safe

PROCHLORPERAZINE EDISYLATE

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and neuroleptic malignant syndrome.

Typical Antipsychotic / Antiemetic

safe

PROCHLORPERAZINE MALEATE

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and neuroleptic malignant syndrome.

Typical Antipsychotic / Antiemetic

safe

Quetiapine

Atypical antipsychotic used for schizophrenia, bipolar disorder, and as an adjunct in treatment-resistant depression. Registry data and cohort studies involving thousands of first-trimester exposures do not demonstrate a consistent pattern of major congenital malformations. However, neonates exposed near delivery can develop extrapyramidal symptoms and neonatal withdrawal syndrome. Associated with gestational diabetes due to metabolic effects. Untreated psychosis or bipolar disorder in pregnancy carries serious maternal and fetal risks.

Atypical Antipsychotic

caution

QUETIAPINE FUMARATE

Strong CYP3A4 inhibitors may increase levels Can cause sedation cataracts and metabolic changes.

Atypical Antipsychotic

safe

REXULTI

Comprehensive clinical and safety monograph for REXULTI (REXULTI).

Atypical Antipsychotic

caution

RISPERDAL

Comprehensive clinical and safety monograph for RISPERDAL (RISPERDAL).

Atypical Antipsychotic

caution

RISPERDAL CONSTA

Comprehensive clinical and safety monograph for RISPERDAL CONSTA (RISPERDAL CONSTA).

Atypical Antipsychotic

caution

RISPERIDONE

Strong CYP2D6 inhibitors may increase levels Can cause hyperprolactinemia and metabolic changes.

Atypical Antipsychotic

safe

RISVAN

Comprehensive clinical and safety monograph for RISVAN (RISVAN).

Atypical Antipsychotic

caution

SAPHRIS

Comprehensive clinical and safety monograph for SAPHRIS (SAPHRIS).

Atypical Antipsychotic

caution

SECUADO

Comprehensive clinical and safety monograph for SECUADO (SECUADO).

Atypical Antipsychotic

caution

SEPHIENCE

Comprehensive clinical and safety monograph for SEPHIENCE (SEPHIENCE).

Atypical Antipsychotic

caution

SEROQUEL

Comprehensive clinical and safety monograph for SEROQUEL (SEROQUEL).

Atypical Antipsychotic

caution

SEROQUEL XR

Comprehensive clinical and safety monograph for SEROQUEL XR (SEROQUEL XR).

Atypical Antipsychotic

caution

SEZABY

Comprehensive clinical and safety monograph for SEZABY (SEZABY).

Atypical Antipsychotic

caution

SYLEVIA

Comprehensive clinical and safety monograph for SYLEVIA (SYLEVIA).

Atypical Antipsychotic

caution

TARACTAN

Comprehensive clinical and safety monograph for TARACTAN (TARACTAN).

Typical Antipsychotic

caution

THIORIDAZINE HYDROCHLORIDE

Strong CYP2D6 inhibitors are contraindicated due to risk of QT prolongation Can cause QT prolongation and retinopathy.

Typical Antipsychotic

safe

THIORIDAZINE HYDROCHLORIDE INTENSOL

Strong CYP2D6 inhibitors are contraindicated due to risk of QT prolongation Can cause QT prolongation and retinopathy.

Typical Antipsychotic

safe

THIOTHIXENE

Comprehensive clinical and safety monograph for THIOTHIXENE (THIOTHIXENE).

Typical Antipsychotic

caution

THIOTHIXENE HYDROCHLORIDE

Comprehensive clinical and safety monograph for THIOTHIXENE HYDROCHLORIDE (THIOTHIXENE HYDROCHLORIDE).

Typical Antipsychotic

caution

THIOTHIXENE HYDROCHLORIDE INTENSOL

Comprehensive clinical and safety monograph for THIOTHIXENE HYDROCHLORIDE INTENSOL (THIOTHIXENE HYDROCHLORIDE INTENSOL).

Typical Antipsychotic

caution

THORAZINE

Comprehensive clinical and safety monograph for THORAZINE (THORAZINE).

Typical Antipsychotic

caution

TOVALT ODT

Comprehensive clinical and safety monograph for TOVALT ODT (TOVALT ODT).

Atypical Antipsychotic

caution

TRIFLUOPERAZINE HCL

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and neuroleptic malignant syndrome.

Typical Antipsychotic

safe

TRIFLUOPERAZINE HYDROCHLORIDE

CNS depressants may enhance sedative effects Can cause extrapyramidal symptoms and neuroleptic malignant syndrome.

Typical Antipsychotic

safe

UZEDY

Comprehensive clinical and safety monograph for UZEDY (UZEDY).

Atypical Antipsychotic

caution

VERSACLOZ

Comprehensive clinical and safety monograph for VERSACLOZ (VERSACLOZ).

Atypical Antipsychotic

caution

VRAYLAR

Comprehensive clinical and safety monograph for VRAYLAR (VRAYLAR).

Atypical Antipsychotic

caution

ZIPRASIDONE HYDROCHLORIDE

Other drugs that prolong the QT interval are contraindicated Can cause QT prolongation and rash.

Atypical Antipsychotic

safe

ZIPRASIDONE MESYLATE

Other drugs that prolong the QT interval are contraindicated Can cause QT prolongation and rash.

Atypical Antipsychotic

safe

ZYPREXA

Comprehensive clinical and safety monograph for ZYPREXA (ZYPREXA).

Atypical Antipsychotic

caution

ZYPREXA RELPREVV

Comprehensive clinical and safety monograph for ZYPREXA RELPREVV (ZYPREXA RELPREVV).

Atypical Antipsychotic

caution

ZYPREXA ZYDIS

Comprehensive clinical and safety monograph for ZYPREXA ZYDIS (ZYPREXA ZYDIS).

Atypical Antipsychotic

caution