Bacterial Meningitis — Uganda (Neonatal population)
Supportive Care
Prevent hypoglycaemia (breastfeed if possible; NGT or IV glucose). Ensure hydration and nutrition. Oxygen if SpO2 <92%.
Empirical Regimen (21 days)
Ampicillin IV: neonate <7 days: 50–100 mg/kg every 12 hours; neonate ≥7 days: 50–100 mg/kg every 8 hours. PLUS Gentamicin 2.5 mg/kg IV every 12 hours.
Group B Streptococcal Meningitis
Benzylpenicillin: neonate ≥7 days: 100,000–150,000 IU/kg IV every 4–6 hours; neonate <7 days: 50,000–100,000 IU/kg IV every 8 hours. PLUS Gentamicin 2.5 mg/kg IV every 12 hours. Continue for 3 weeks total.
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