Uganda guidelines for the treatment of Brucellosis
Uganda Clinical Guidelines 2023 · all from source →
General Adult
Diagnosis
Clinical Features
Intermittent (undulant) fever. Aches and pains. Orchitis (inflammation of the testes in men). Vertebral osteomyelitis (uncommon but characteristic). Risk: contact with cattle, goats, sheep, pigs, dogs; drinking unpasteurised milk; handling contaminated meat.
Investigations
Blood: complement fixation test or agglutination test. Isolation of infectious agent from blood, bone marrow, or other tissues by culture.
Screening
Drink only pasteurised or boiled milk.
Careful handling of pigs, goats, dogs, and cattle — use protective equipment.
Public health education on risk of transmission from contaminated meat.
Treatment
Adults and Children >8 Years (HC4)
Doxycycline 100 mg every 12 hours for 6 weeks. PLUS Gentamicin 5–7 mg/kg IV daily for 2 weeks. Alternative to Gentamicin: Ciprofloxacin 500 mg twice daily for 2 weeks (not for children <12 years).
Children <8 Years
Cotrimoxazole 24 mg/kg every 12 hours for 6 weeks. PLUS Gentamicin 5–7 mg/kg IV in single or divided doses for 2 weeks.
Cautions
Treatment duration must be adhered to at all times. Ciprofloxacin is contraindicated in children <12 years. Doxycycline and Gentamicin are contraindicated in pregnancy.
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