Epilepsy Pregnancy — United States (Pregnancy population)
When treating PWECP using acetazolamide, eslicarbazepine, ethosuximide, lacosamide, nitrazepam, perampanel, piracetam, pregabalin, rufinamide, stiripentol, tiagabine, or vigabatrin
Clinicians should counsel their patients that there are limited data on pregnancy-related outcomes for these drugs.
Regarding fetal outcomes
Clinicians should counsel PWECP that the prevalence of intrauterine death does not differ among different ASM exposures in monotherapy.
When treating PWECP
Clinicians should counsel that adherence to recommended folic acid supplementation preconceptionally and during pregnancy is important to minimize the risk of MCMs and poor neurodevelopmental outcomes.
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