Paracetamol Poisoning — Uganda (General Adult population)
Clinical Features — Early (0–24 hours)
Often asymptomatic initially. Nausea, vomiting, malaise. May appear deceptively well.
Clinical Features — Late (24–72 hours)
Right upper quadrant abdominal pain. Jaundice. Liver failure (elevated transaminases, prolonged PT). Renal failure may develop.
High Risk Thresholds
Single adult dose: >150 mg/kg or >7.5 g is potentially toxic. Toxicity is enhanced in patients with hepatic disease, chronic alcohol use, malnutrition, or on enzyme-inducing drugs.
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