Clinical management of Sickle Cell Disease in Uganda

Prophylaxis (0-5 years)

Phenoxymethylpenicillin 125 mg twice daily + Folic acid 2.5-5 mg daily.

Fever

Treat as medical emergency. Broad-spectrum antibiotics (e.g. Ceftriaxone) if bacterial infection suspected.

Prophylaxis

Folic acid 5 mg once daily. Ensure good hydration and nutrition.

Painful Crisis (Mild)

Paracetamol 1 g every 6-8 hours or Ibuprofen 400 mg every 8 hours.

Painful Crisis (Severe)

Morphine 5-10 mg SC or IM every 4 hours or IV 2-5 mg every 1-4 hours.

Maintenance (Chronic)

Hydroxyurea 15-20 mg/kg once daily. Monitor blood counts.