What are the limitations of the revised nhl response?

While the revised nhl response is highly validated, it should not replace clinical judgment. OpiCalc provides the latest evidence-based limitations for the revised nhl response to ensure safe bedside use and optimal diagnostic accuracy.

How does the revised nhl response compare to other Hematology scores?

The revised nhl response is a gold-standard diagnostic tool. OpiCalc provides side-by-side clinical guidance to help clinicians choose the most specific evidence-based tool for their patient's presentation.

Is the revised nhl response free to use?

Yes. OpiCalc provides the revised nhl response completely ad-free and optimized for mobile bedside use, ensuring you can calculate medical risk swiftly and without distraction.

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Revised Response Criteria (NHL)

Lugano 2014 Response: Integrates Deauville Score with anatomical size changes.

End of Treatment Deauville Score

1-3 = PET Negative, 4-5 = PET Positive

Size Change (Sum of Prod.)

New Lesions

Refined Lugano Response

Pending...

Select Deauville and Anatomical metrics to determine response.

Guidelines & Evidence

Clinical Details

Section 1

When to Use

Defining the depth of response (CR, PR, SD, PD) in patients with aggressive or indolent NHL.

End-of-treatment assessment using PET-CT (for FDG-avid lymphomas) or CT (for non-avid lymphomas).

Standardizing response reporting in clinical trials.

Patient Population

Adult and pediatric patients undergoing immunochemo- or targeted therapy for lymphoma.

When Not to Rely on This Score Alone

Interim PET — while Lugano defines response, "interim" PET (e.g., after 2 cycles) requires specific Deauville score interpretation for therapy escalation/de-escalation.

CLL response — CLL has its own dedicated (iwCLL) response criteria.

Section 2

Formula & Logic

Response Categories (PET-based)

Category	Nodal Response	Bone Marrow
CR (Complete)	Deauville 1, 2, or 3 with or without a residual mass.	Normal by PET/Morphology.
PR (Partial)	Deauville 4 or 5 with reduced uptake from baseline and reduced size.	No specific requirement; residual PET uptake ok.
SD (Stable)	Deauville 4 or 5 with no significant change in uptake or size.	N/A
PD (Progressive)	Deauville 4 or 5 with increase in uptake OR any new FDG-avid lesion.	New or recurrent involvement.

Section 3

Pearls/Pitfalls

The Residual Mass

One of the most important aspects of Lugano/Cheson 2014 is that a residual anatomical mass does NOT preclude a Complete Response (CR) if the PET is negative (Deauville 1–3). This reflects that residual fibrosis is common even after successful therapy.

Section 4

Evidence Appraisal

Primary Consensus

Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.

Cheson BD et al. • Journal of Clinical Oncology. 2014;32(27):3059-68.

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Section 5

Literature

Integration

Updates the previous Cheson 2007 (IWG) criteria by formally integrating PET-CT and the 5-point Deauville scale as the primary modality for response assessment in FDG-avid histologies.

Last Comprehensive Review: 2026

Related Hematology Tools

IPSID / Lugano Classification

Deauville Score Interpreter

CLL-IPI

Binet / Rai Staging

iwCLL Response Criteria

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