Pyrimethamine-Sulfadoxine
Combination used for Intermittent Preventive Treatment in Pregnancy (IPTp) — a WHO-recommended malaria prevention strategy for sub-Saharan Africa. Given at each ANC visit from 13 weeks onward (not T1) at least 4 weeks apart. Reduces risk of maternal anaemia, LBW, and perinatal mortality in malaria-endemic settings. Pyrimethamine is a folate antagonist — co-administer with folic acid 5 mg/day. Avoid in T1 (folate antagonism during organogenesis). Sulfadoxine carries sulfonamide risk at term.
