Clinimix 5/35 sulfite free in dextrose 35% in plastic container
Clinical Indications
Maximum-calorie parenteral nutrition for severely fluid-restricted patients requiring aggressive nutritional support.
Dosing & Administration Rate
Requires intensive glucose monitoring and likely continuous insulin infusion.
Warnings & Precautions
Highest osmolarity formulation. Strictly central administration. Monitor for severe hyperglycaemia and hyperosmolar states.
Contraindications
Known hypersensitivity to amino acids. Severe liver disease or hepatic coma. Severe renal impairment (without dialysis). Abnormalities of amino acid metabolism.
Pharmacology & Safety Profile
Mechanism of Action
Provides a source of biologically utilizable essential and non-essential amino acids for protein synthesis, and dextrose as a source of calories.
Adverse Reactions
Phlebitis, fluid overload, hyperglycemia, hyperosmolar syndrome, electrolyte imbalances, metabolic acidosis, liver enzyme elevations.
Compatibility Notes
Pharmacy addition of electrolytes required.
Electrolyte & Composition Profile
| Component | Amount / Concentration |
|---|---|
| Amino Acids | 50 g/L (5%) |
| Dextrose (Anhydrous) | 350 g/L (35%) |
| Water for Injection | q.s. |
| Caloric Density | 1,190 kcal/L (from dextrose), 200 kcal/L (from protein) |
| Nitrogen Content | 8 g/L |
Clinical Parameters
Clinical Disclaimer: Data compiled from FDA DailyMed, Baxter/Fresenius prescribing information, and USP monographs. Always verify against the physical product label, your institution's IV protocols, and current pharmacist guidance before administration.
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