What are the limitations of the aps classification?

While the aps classification is highly validated, it should not replace clinical judgment. OpiCalc provides the latest evidence-based limitations for the aps classification to ensure safe bedside use and optimal diagnostic accuracy.

How does the aps classification compare to other hematology scores?

The aps classification is a gold-standard diagnostic tool. OpiCalc provides side-by-side clinical guidance to help clinicians choose the most specific evidence-based tool for their patient's presentation.

Is the aps classification free to use?

Yes. OpiCalc provides the aps classification completely ad-free and optimized for mobile bedside use, ensuring you can calculate medical risk swiftly and without distraction.

OpiCalc

927 Clinical Tools

OpiCalc

4Ts Score (HIT)aaIPI (Age-adjusted IPI)ABC Score (Massive Transfusion)Absolute Neutrophil Count Age-adjusted D-dimer Threshold aGvHD Grading (Glucksberg/MAGIC)AL Amyloidosis Staging (Mayo)Anti-Xa Monitoring Interpreter Antiphospholipid Syndrome Classification Binet / Rai Staging (CML)Blood Volume Calculator Caprini VTE Risk CISNE Score CLL-IPI Coombs-Negative Haemolysis Checklist Corrected Reticulocyte Count CRS Grading (ASTCT 2019)DAT Interpretation Algorithm Deauville Score Interpreter DIC Score (ISTH)DIPSS (MF)DIPSS-Plus (MF)DOAC Dose Selector DOAC Renal Dose Adjustment DRI (Disease Risk Index)Durie-Salmon Staging (historical)EBMT Risk Score ELN 2022 AML Risk Classification ELTS Score (CML)England & Fraser Index EUTOS Score (CML)Expected Hb Rise per RBC Unit Factor Inhibitor Bethesda Titre Interpreter Febrile Neutropaenia Risk (MASCC)Fibrinogen Replacement FLIPI (Follicular Lymphoma IPI)FLIPI-2 French TTP Score GAPSS (Global APS Score)Haemophilia Severity Classification HbS Percentage Target Calculator HCT-CI (Comorbidity Index)HEP Score Heparin Nomogram (Weight-based)Hepatic Iron Index HERDOO2 Rule HFE Haemochromatosis Risk Estimator ICANS Grading (ASTCT 2019)IMWG Response Criteria (Myeloma)IPI (International Prognostic Index)IPSID / Lugano Classification IPSS-M (Molecular IPSS)IPSS-R (Revised IPSS for MDS)Iron Deficit Calculator (Ganzoni Formula)ISS (Myeloma)ISTH Bleeding Assessment Tool (BAT)ISTH Non-Overt DIC Score ITP Bleeding Score iwCLL Response Criteria (2018)IWG ITP Response Criteria JAK2V617F Allele Burden Interpreter Karnofsky Performance Scale Leucostasis Risk Threshold Lupus Anticoagulant (LAC) Reporting Framework MAGIC aGvHD Biomarker Score MCV-based Anaemia Algorithm Mentzer Index MIPI (MCL IPI)MIPSS70+ v2.0 (MF)Mixing Study Interpretation MRD Assessment Threshold Interpreter mSMART 3.0 (Myeloma)MTP Activation Criteria NCCN-IPI NIH Chronic GvHD Scoring NTDT Iron Burden Estimator Padua RAM PBT (Paediatric BAT)PCNSL MSKCC Score PERC Rule Perioperative Anticoagulation Bridging PESI Score (PE Mortality)PLASMIC Score Platelet Increment Calculator (CCI)PNH Clone Size Interpreter R-IPI (Revised IPI)R-ISS (Revised ISS)Reticulocyte Index (RPI)Revised Geneva Score (PE)Revised Response Criteria (NHL)Revised Zubrod / ECOG Performance Shine & Lal Index Sickle Cell Disease Risk (TCD)SLiM-CRAB Criteria SOKAL Score (CML)Sokal/EUTOS/ELTS Comparison sPESI (Simplified PESI)TACO Risk Score Thalassaemia Transfusion Threshold Thrombocytopaenia Differential Thrombophilia Screening Eligibility Algorithm Time in Therapeutic Range (TTR)TLS Risk Classification Transferrin Saturation Calculator Vienna Prediction Model von Willebrand Factor Activity Interpreter Warfarin Dose Calculator Wells Score (DVT)Wells Score (PE)WHO 2022 AML Classification Mapper WHO Bleeding Scale YEARS Algorithm

Antiphospholipid Syndrome Classification

APS Classification (Revised Sapporo): Definite APS requires at least one clinical criterion and at least one laboratory criterion.

Clinical Criteria

Clinical Unmet

Laboratory Criteria

Lab Unmet

Diagnostic Status

Criteria Not Met

Clinical

Lab

Guidelines & Evidence

Clinical Details

Section 1

When to Use

Clinical Use

Used for the classification of Antiphospholipid Syndrome in research and clinical settings. Definite APS requires one clinical and one laboratory criterion.

Section 2

Formula & Logic

Clinical Criteria

Vascular Thrombosis: One or more clinical episodes of arterial, venous, or small vessel thrombosis.

Pregnancy Morbidity: One death of morphologically normal fetus ≥ 10 weeks OR three premature births before 34 weeks due to eclampsia/placental insufficiency OR three or more unexplained consecutive spontaneous abortions < 10 weeks.

Laboratory Criteria

Lupus Anticoagulant (LA) present in plasma on two or more occasions at least 12 weeks apart.

Anticardiolipin (aCL) antibody (IgG/IgM) > 40 GPL/MPL units on two/more occasions 12 weeks apart.

Anti-β2 glycoprotein-I antibody (IgG/IgM) > 99th percentile on two/more occasions 12 weeks apart.

Section 3

Evidence Appraisal

Primary Reference

International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)

Miyakis S et al. • Journal of Thrombosis and Haemostasis. 2006;4(2):295-306

Last Comprehensive Review: 2026

Related Hematology Tools

Age-adjusted D-dimer Threshold

sPESI

HEP Score

HERDOO2 Rule

Vienna Prediction Model

Padua RAM

Have feedback about this calculator?Let us know.

Antiphospholipid Syndrome Classification

APS Classification (Revised Sapporo): Definite APS requires at least one clinical criterion and at least one laboratory criterion.

Clinical Criteria

Clinical Unmet

Laboratory Criteria

Lab Unmet

Diagnostic Status

Criteria Not Met

Clinical

Lab

Guidelines & Evidence

Clinical Details

Section 1

When to Use

Clinical Use

Used for the classification of Antiphospholipid Syndrome in research and clinical settings. Definite APS requires one clinical and one laboratory criterion.

Section 2

Formula & Logic

Clinical Criteria

Vascular Thrombosis: One or more clinical episodes of arterial, venous, or small vessel thrombosis.

Laboratory Criteria

Lupus Anticoagulant (LA) present in plasma on two or more occasions at least 12 weeks apart.

Anticardiolipin (aCL) antibody (IgG/IgM) > 40 GPL/MPL units on two/more occasions 12 weeks apart.

Anti-β2 glycoprotein-I antibody (IgG/IgM) > 99th percentile on two/more occasions 12 weeks apart.

Section 3

Evidence Appraisal

Primary Reference

International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)

Miyakis S et al. • Journal of Thrombosis and Haemostasis. 2006;4(2):295-306

Last Comprehensive Review: 2026

Related Hematology Tools

Age-adjusted D-dimer Threshold

sPESI

HEP Score

HERDOO2 Rule

Vienna Prediction Model

Padua RAM

Have feedback about this calculator?Let us know.