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ACMG/AMP Variant Classifier

ACMG/AMP Variant Classification (2015)

Select all applicable evidence criteria. The framework combines evidence strength to generate a 5-tier variant classification (P → LP → VUS → LB → B). This is a decision-support tool — final classification requires expert molecular pathologist review.

Pathogenic Evidence Criteria

Benign Evidence Criteria

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Interpreting variants identified in clinical genetic testing panels, exomes, or whole-genome sequencing.

Classifying germline variants from hereditary cancer, cardiovascular, neurological, or metabolic gene panels.

Structuring evidence for VUS (Variant of Uncertain Significance) review and reclassification decisions.

Standard framework used by all ACMG-accredited clinical laboratories and required for CAP/CLIA certification.

Last Comprehensive Review: 2026