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ACMG/AMP Variant ClassifierAmsterdam Criteria IICYP2C19 Phenotype InterpreterDLCN Score (FH)GJB2 Variant InterpreterGhent-2 Criteria (Marfan)HTT CAG Repeat (Huntington)Hereditary Thrombophilia VTE RiskRevised Bethesda GuidelinesTyrer-Cuzick Breast Risk
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DLCN Score (FH)

Dutch Lipid Clinic Network Score

Diagnoses Familial Hypercholesterolaemia (FH). Score > 8 = Definite FH. Use untreated LDL-C (×1.43 if on moderate statin, ×1.67 if high-intensity).

Family History

Clinical History

Physical Examination

LDL-C (Untreated mmol/L)

DNA Analysis

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

Diagnosing Familial Hypercholesterolaemia (FH) in adults presenting with elevated LDL-C.
Triage before genetic testing — DLCN score of Definite or Probable FH should trigger cascade testing of family members.
Endorsed by EAS, ESC, NICE (UK), Heart UK, and FH Foundation as the primary adult FH diagnostic score.
Applicable in primary care and lipid clinic settings; requires family history, clinical features, and fasting lipid profile.

Last Comprehensive Review: 2026