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Tyrer-Cuzick Breast Risk

Simplified Estimation Only

For full clinical IBIS Tyrer-Cuzick calculation, use ibis-risk-calculator.magview.com. This module provides a risk category approximation based on key variables.

Tyrer-Cuzick (IBIS) Breast Cancer Risk

Multifactorial breast cancer risk model integrating family history, hormonal factors, BRCA probability, ADH/LCIS, and density. Endorsed by NICE NG101, ACMG, NCCN.

Current Age

1st-Degree Relatives with Breast Cancer

2nd-Degree Relatives with Breast Cancer

BRCA Status

Atypical Ductal Hyperplasia (ADH) or ALH on Biopsy?

LCIS (Lobular Carcinoma In Situ)?

Mammographic Density (BI-RADS)

Ashkenazi Jewish Ancestry?

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Estimating 10-year and lifetime risk of breast cancer for surveillance and chemoprevention decisions.

Identifying women who should be offered enhanced surveillance (annual MRI) beyond standard mammography.

Triaging candidates for BRCA1/2 and expanded hereditary breast cancer gene panel testing.

Endorsed by NICE (UK), ACMG, NCCN, and ASBrS as a comprehensive multifactorial risk model.

What Makes IBIS Different

Tyrer-Cuzick is the most comprehensive individual risk model — integrating family history (both sides), hormonal factors, BRCA carrier probability, density, and atypical hyperplasia in a single Bayesian framework. It consistently outperforms Gail model for women with strong family history.

Last Comprehensive Review: 2026