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Radiation Oncology

RPA Grading for Brain Metastases

Prognostic Tool: RPA Grading

Classic Classification

Enter patient status and disease control to determine the RPA class and median survival estimate.

Guidelines & Evidence

Verified

Last Review: 2026

RPA Classes

Defining the Three Classes

The RPA was developed using a recursive partitioning algorithm to identify the variables that most strongly predict survival. It remains one of the most widely used systems in clinical trials and bedside practice due to its simplicity.

The Classification Criteria

RPA ClassClinical RequirementsMedian Survival (Months)
Class IKPS ≥ 70, Age < 65 years, Controlled Primary, No Extracranial Metastases.7.1
Class IIIKPS < 70 (Regardless of all other factors).2.3
Class IIAll patients not in Class I or III.4.2

Last Comprehensive Review: 2026