Radiation Oncology

DS-GPA Score (Diagnosis-Specific GPA)

Oncology Core: Diagnosis-Specific GPA

Primary Tumor Type

KPS (Performance Status)

Age

Molecular Status

Extracranial Disease

Molecular Precision

Select the primary tumor histology and molecular markers to generate a histology-specific survival estimate.

Guidelines & Evidence

Verified

Last Review: 2026

Histological Precision

Why DS-GPA?

The original GPA treated all brain metastases the same. However, research showed that a patient with breast cancer and brain mets has a vastly different prognosis than a patient with lung cancer. The DS-GPA refines the scoring by selecting the most relevant prognostic factors for each specific cancer type. For example, in Lung Cancer, EGFR/ALK status is included, while in Breast Cancer, HER2 status is paramount.

NSCLC DS-GPA Factors

Factor	0 Points	0.5 Points	1.0 Point	2.0 Points
KPS (%)	< 70	70 – 80	90 – 100	N/A
Age (years)	> 70	N/A	< 70	N/A
Gene Markers	Negative/Unknown	N/A	N/A	EGFR/ALK+
Extracranial Mets	Present	N/A	None	N/A

Breast Cancer DS-GPA Factors

Factor	0 Points	1.0 Point	1.5 Points	2.0 Points
KPS (%)	< 60	60 – 80	N/A	90 – 100
Subtype	Basal (Triple Neg)	N/A	Luminal B	HER2+
Age (years)	> 60	< 60	N/A	N/A

Last Comprehensive Review: 2026