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Radiation Oncology

DS-GPA Score (Diagnosis-Specific GPA)

Oncology Core: Diagnosis-Specific GPA

Primary Tumor Type

KPS (Performance Status)

Age

Molecular Status

Extracranial Disease

Molecular Precision

Select the primary tumor histology and molecular markers to generate a histology-specific survival estimate.

Guidelines & Evidence

Verified

Last Review: 2026

Histological Precision

Why DS-GPA?

The original GPA treated all brain metastases the same. However, research showed that a patient with breast cancer and brain mets has a vastly different prognosis than a patient with lung cancer. The DS-GPA refines the scoring by selecting the most relevant prognostic factors for each specific cancer type. For example, in Lung Cancer, EGFR/ALK status is included, while in Breast Cancer, HER2 status is paramount.

NSCLC DS-GPA Factors

Factor	0 Points	0.5 Points	1.0 Point	2.0 Points
KPS (%)	< 70	70 – 80	90 – 100	N/A
Age (years)	> 70	N/A	< 70	N/A
Gene Markers	Negative/Unknown	N/A	N/A	EGFR/ALK+
Extracranial Mets	Present	N/A	None	N/A

Breast Cancer DS-GPA Factors

Factor	0 Points	1.0 Point	1.5 Points	2.0 Points
KPS (%)	< 60	60 – 80	N/A	90 – 100
Subtype	Basal (Triple Neg)	N/A	Luminal B	HER2+
Age (years)	> 60	< 60	N/A	N/A

Related Scores in Practice

In clinical practice, this assessment is frequently evaluated alongside other validated measures. Depending on the patient's presentation and specific diagnostic requirements, you may also need to utilize the Gpa Brain Mets, Rpa Grading Brain Mets or the SRS Dose Selection (RTOG) to formulate a comprehensive care plan.

Last Comprehensive Review: 2026