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eGFR (CKD-EPI)

Standard eGFR

CKD-EPI 2021 Race-Free

Serum Creatinine

Creatinine (mg/dL)

Patient Age (Years)

Biological Sex

CKD-EPI 2021 · Race-free · Accepts mg/dL or µmol/L

Renal Intelligence

Enter serum creatinine (mg/dL or µmol/L) and age to compute filtration rate.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Primary tool for estimating GFR in stable adult patients with steady-state serum creatinine.

Staging Chronic Kidney Disease (CKD) per KDIGO 2024 guidelines and tracking longitudinal progression.

Screening at-risk populations: Type 2 Diabetes, Hypertension, Obesity, Cardiovascular disease, Family history of CKD, Recurrent nephrolithiasis, Autoimmune disease.

Determining eligibility and dosing thresholds for renally-cleared drugs including DOACs, Metformin, SGLT2 inhibitors, and NSAIDs.

Pre-procedural risk assessment prior to iodinated contrast administration or nephrotoxic agent exposure.

Transplant evaluation: donor and recipient workup for living kidney donation.

Monitoring disease trajectory in conjunction with UACR to guide referral and intensification of treatment.

Inclusion Criteria

Adults aged 18 years and older with a stable serum creatinine reflecting steady-state GFR. Both SI units (µmol/L) and conventional units (mg/dL) are fully supported. The calculator auto-converts between units in real time — toggling units will carry over the entered value. Always confirm which unit your laboratory report uses before entering a value.

Absolute Contraindications

Do not apply in Acute Kidney Injury (AKI) — creatinine is still rising and does not reflect true filtration. Do not use in patients on dialysis, post-nephrectomy with single kidney in non-steady state, or in acute tubular necrosis. Do not use for pediatric patients (use Bedside Schwartz or CKiD U25 equation instead).

Relative Limitations

Extremes of muscle mass (sarcopenia, bodybuilders, amputees, malnutrition) distort the creatinine-GFR relationship.

Pregnancy: GFR naturally rises 40–65% by second trimester; CKD-EPI underestimates true GFR.

Liver cirrhosis: reduced hepatic creatine synthesis lowers serum creatinine independently of GFR.

High meat intake acutely raises serum creatinine (cooked meat releases creatine → creatinine), transiently lowering the eGFR estimate.

Medications that competitively inhibit tubular creatinine secretion (Trimethoprim, Cimetidine, Cobicistat) raise serum creatinine without affecting true GFR.

Related Scores in Practice

In clinical practice, this assessment is frequently evaluated alongside other validated measures. Depending on the patient's presentation and specific diagnostic requirements, you may also need to utilize the Creatinine Clearance Multi-Method, CKD Stage (KDIGO), Kfre Calc, UACR, CHA2DS2-VASc, HAS-BLED or the ORBIT Score to formulate a comprehensive care plan.

Last Comprehensive Review: 2026

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