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Creatinine Clearance

Creatinine Clearance Calculator

Cockcroft-Gault Equation

Diagnostic Parameters

Age (Years)

Total Weight (kg)

Serum Creatinine (mg/dL)

Biological Sex

Cockcroft-Gault remains the standard for drug dosing.

Drug Clearance Engine

Enter metrics to execute Cockcroft-Gault dosing verification.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

Core Clinical Uses

Primary method for renal drug dosing adjustment (FDA labeling standard).

Estimation of kidney function in stable adult patients using serum creatinine.

Baseline renal function assessment prior to initiating nephrotoxic medications.

Monitoring renal function trends in chronic kidney disease (CKD).

Dose individualisation for narrow therapeutic index drugs (e.g., aminoglycosides, vancomycin, lithium, digoxin).

High-Impact Clinical Scenarios

Sepsis and ICU patients receiving renally cleared antibiotics.

HIV/TB patients on tenofovir, aminoglycosides, or amphotericin B.

Elderly patients with polypharmacy and reduced muscle mass.

Oncology patients receiving nephrotoxic chemotherapy.

When NOT to Use

Avoid use in acute kidney injury (AKI) or rapidly changing creatinine levels. Not validated in children, pregnancy, or patients with extreme body composition (e.g., amputees, severe obesity) without appropriate adjustments. In ICU patients, may significantly misrepresent true GFR.

Related Scores in Practice

In clinical practice, this assessment is frequently evaluated alongside other validated measures. Depending on the patient's presentation and specific diagnostic requirements, you may also need to utilize the eGFR (CKD-EPI), Aminoglycoside Extended-Interval Dosing, Aminoglycoside Traditional Dosing, Creatinine Clearance Multi-Method or the Adjusted Body Weight to formulate a comprehensive care plan.

Last Comprehensive Review: 2026