Clinimix E 5/10 sulfite free w/ elect in dextrose 10% w/ calcium
Clinical Indications
High-protein TPN for hypermetabolic patients (sepsis, major trauma, burns) with moderate caloric requirements. 5% amino acid concentration exceeds standard formulations.
Dosing & Administration Rate
Monitor renal function — high nitrogen load. 1.5–2 g protein/kg/day provided at standard rates.
Warnings & Precautions
High amino acid load — contraindicated in severe renal failure without specialist guidance. Standard TPN monitoring applies.
Contraindications
Known hypersensitivity to amino acids. Severe liver disease or hepatic coma. Severe renal impairment (without dialysis). Abnormalities of amino acid metabolism.
Pharmacology & Safety Profile
Mechanism of Action
Provides a source of biologically utilizable essential and non-essential amino acids for protein synthesis, and dextrose as a source of calories.
Adverse Reactions
Phlebitis, fluid overload, hyperglycemia, hyperosmolar syndrome, electrolyte imbalances, metabolic acidosis, liver enzyme elevations.
Compatibility Notes
Vitamins and trace elements supplemented per protocol.
Electrolyte & Composition Profile
| Component | Amount / Concentration |
|---|---|
| Amino Acids | 50 g/L (5%) |
| Dextrose (Anhydrous) | 100 mg/mL (10%) |
| Electrolytes (Na, K, Ca, Mg, Phosphate) | Standard Clinimix E panel |
| Nitrogen Content | ≈ 7.7 g/L |
| Caloric Density | ≈ 740 kcal/L |
| Nitrogen Content | 7.7 g N/L |
Clinical Parameters
Clinical Disclaimer: Data compiled from FDA DailyMed, Baxter/Fresenius prescribing information, and USP monographs. Always verify against the physical product label, your institution's IV protocols, and current pharmacist guidance before administration.
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