Clinimix E 5/15 sulfite free w/ elect in dextrose 15% w/ calcium
Clinical Indications
Balanced high-protein, moderate-glucose TPN. Provides >1,000 kcal/L with high nitrogen content — suited for catabolic ICU patients requiring both protein repletion and energy.
Dosing & Administration Rate
Glucose:nitrogen ratio approximately 150 g dextrose per 7.7 g N. Monitor glucose, electrolytes, and weekly LFTs.
Warnings & Precautions
Central access required. Hyperglycaemia common — insulin protocol. High nitrogen requires monitoring of renal function and BUN.
Contraindications
Known hypersensitivity to amino acids. Severe liver disease or hepatic coma. Severe renal impairment (without dialysis). Abnormalities of amino acid metabolism.
Pharmacology & Safety Profile
Mechanism of Action
Provides a source of biologically utilizable essential and non-essential amino acids for protein synthesis, and dextrose as a source of calories.
Adverse Reactions
Phlebitis, fluid overload, hyperglycemia, hyperosmolar syndrome, electrolyte imbalances, metabolic acidosis, liver enzyme elevations.
Compatibility Notes
Standard TPN admixture additions.
Electrolyte & Composition Profile
| Component | Amount / Concentration |
|---|---|
| Amino Acids | 50 g/L (5%) |
| Dextrose (Anhydrous) | 150 mg/mL (15%) |
| Electrolytes (Na, K, Ca, Mg, Phosphate) | Standard Clinimix E panel |
| Nitrogen Content | ≈ 7.7 g/L |
| Caloric Density | ≈ 1,010 kcal/L |
| Nitrogen Content | 7.7 g N/L |
Clinical Parameters
Clinical Disclaimer: Data compiled from FDA DailyMed, Baxter/Fresenius prescribing information, and USP monographs. Always verify against the physical product label, your institution's IV protocols, and current pharmacist guidance before administration.
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