Clinimix E 5/20 sulfite free w/ elect in dextrose 20% w/ calcium
Clinical Indications
Concentrated high-protein, high-calorie TPN for fluid-restricted hypermetabolic patients. ICU and oncology settings where volume limitation is critical.
Dosing & Administration Rate
High caloric density — small volume per day meets full nutritional requirements. Monitor glucose, electrolytes, and liver function closely.
Warnings & Precautions
Very high osmolarity — central access mandatory. Strict glucose management with insulin protocol. Standard TPN safety monitoring.
Contraindications
Known hypersensitivity to amino acids. Severe liver disease or hepatic coma. Severe renal impairment (without dialysis). Abnormalities of amino acid metabolism.
Pharmacology & Safety Profile
Mechanism of Action
Provides a source of biologically utilizable essential and non-essential amino acids for protein synthesis, and dextrose as a source of calories.
Adverse Reactions
Phlebitis, fluid overload, hyperglycemia, hyperosmolar syndrome, electrolyte imbalances, metabolic acidosis, liver enzyme elevations.
Compatibility Notes
CVC. Vitamins and trace elements per protocol.
Electrolyte & Composition Profile
| Component | Amount / Concentration |
|---|---|
| Amino Acids | 50 g/L (5%) |
| Dextrose (Anhydrous) | 200 mg/mL (20%) |
| Electrolytes (Na, K, Ca, Mg, Phosphate) | Standard Clinimix E panel |
| Nitrogen Content | ≈ 7.7 g/L |
| Caloric Density | ≈ 1,280 kcal/L |
| Nitrogen Content | 7.7 g N/L |
Clinical Parameters
Clinical Disclaimer: Data compiled from FDA DailyMed, Baxter/Fresenius prescribing information, and USP monographs. Always verify against the physical product label, your institution's IV protocols, and current pharmacist guidance before administration.
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