ALDEN Algorithm

ALDEN (Algorithm of Drug Causality for Epidermal Necrolysis) is applied per-drug in a patient with confirmed Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) to determine which medication(s) among all those the patient is taking are most likely responsible. It is specifically designed for the SJS/TEN context — with timing windows, dechallenge and rechallenge weights calibrated to the distinctive immunopathology of epidermal necrolysis.