Recent Journal Updates

DiabetologiaJun 6, 2026

Plasma small RNA profiling reveals a three-miRNA signature associated with early beta cell dysfunction across glucose tolerance stages

Clinical Context

We think this might be relevant to the clinical guidance for AGEP Validation Score (EuroSCAR).

Cancer MedicineJun 6, 2026

Development and Validation of a Predictive Nomogram for Diagnosing Colorectal Cancer Based on Immune‐Nutritional Score

Clinical Context

We think this might be relevant to the clinical guidance for AGEP Validation Score (EuroSCAR).

DiabetologiaJun 6, 2026

SARS-CoV-2 infection and COVID-19 vaccination and the risk for new-onset type 1 diabetes: a register-based population study in Sweden

Clinical Context

We think this has broad domain relevance to AGEP Validation Score (EuroSCAR).

AGEP Score

AGEP Validation Score: Differentiates drug eruptions from pustular psoriasis.

Diagnostic Criteria

Typical Pustules (Non-follicular)

Typical Erythema (Redness)

Rapid Evolution (<10 days)

Fever ≥ 38°C (100.4°F)

Neutrophils > 7000/μL

Awaiting Inputs

Select the clinical findings and laboratory markers to validate the probability of AGEP.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

The EuroSCAR AGEP Validation Score is used to standardize the diagnosis of Acute Generalized Exanthematous Pustulosis (AGEP) and differentiate it from other severe pustular dermatoses, including pustular psoriasis, subcorneal pustular dermatosis, and other severe cutaneous adverse reactions (SCARs). It is applied to any patient presenting with an acute, generalized pustular eruption — particularly in the context of recent drug exposure.

Primary Indications

Acute onset of ≥ dozens of sterile non-follicular pustules on erythematous/edematous skin

Fever ≥ 38°C accompanying or preceding the pustular eruption

Recent drug exposure (most commonly aminopenicillins, macrolides, pristinamycin, diltiazem)

Peripheral blood neutrophilia (≥ 7 × 10⁹/L)

Rapid spontaneous resolution expected within 15 days of drug withdrawal

When NOT to Use

Known generalized pustular psoriasis without drug trigger (different pathophysiology)

Neonates and infants — clinical criteria differ significantly

When skin biopsy is unavailable (histology carries the highest discriminating weight)

As a drug causality tool — use ALDEN for per-drug attribution in confirmed AGEP

Related Scores in Practice

In clinical practice, this assessment is frequently evaluated alongside other validated measures. Depending on the patient's presentation and specific diagnostic requirements, you may also need to utilize the RegiSCAR DRESS Validation, ALDEN Algorithm or the SCORTEN to formulate a comprehensive care plan.

Last Comprehensive Review: 2026