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Recent Journal Updates

DiabetologiaJun 6, 2026

Time-restricted eating versus dietetic guidance on glycaemic outcomes in adults at risk of type 2 diabetes: a non-inferiority randomised clinical trial

Clinical Context

We think this has broad domain relevance to SCORTEN (SJS/TEN Severity Score).

Alzheimers & DementiaJun 3, 2026

Association of imaging‐defined brain age with disease severity and adverse outcomes in CADASIL

Clinical Context

We think this might be relevant to the clinical guidance for SCORTEN (SJS/TEN Severity Score).

DiabetologiaMay 26, 2026

Clinical and psychological phenotypes of type 1 diabetes and disordered eating derived from a case vignette series: T1DE phenotypes

Clinical Context

We think this might be relevant to the clinical guidance for SCORTEN (SJS/TEN Severity Score).

SCORTEN

SCORTEN: Cross-linked SCORTEN severity scoring for severe cutaneous drug reactions relevant to infectious differentials.

SCORTEN: Validated prognostic score for SJS and Toxic Epidermal Necrolysis.

Prognostic Indicators

Risk Prediction

Select the clinical and laboratory criteria present on Day 1 to calculate the survival probability using the SCORTEN model.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

SCORTEN (SCORe of Toxic Epidermal Necrosis) is a validated 7-variable severity-of-illness score that predicts in-hospital mortality for patients admitted with Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN). It is calculated within the first 24 hours of admission and should be repeated on Day 3 for prognostic refinement. It is the globally accepted standard mortality risk tool for SJS/TEN.

Primary Indications

SJS: < 10% BSA epidermal detachment with mucosal involvement and target lesions

SJS-TEN overlap: 10–30% BSA epidermal detachment

TEN: > 30% BSA epidermal detachment (Nikolsky positive)

Triaging to burn unit, medical ICU, or specialized dermatology centre based on predicted mortality

Prognostic communication with patient, family, and multidisciplinary team

Benchmarking outcomes in SJS/TEN case series and quality improvement

When NOT to Use

DRESS syndrome — use RegiSCAR scoring; SCORTEN variables are not validated for DRESS

AGEP — distinct pathology; self-limited; SCORTEN is inappropriate

Fixed drug eruption or morbilliform drug rash without epidermal detachment

As a substitute for clinical monitoring — SCORTEN is prognostic, not a management protocol

Timing Requirement

Calculate SCORTEN within the first 24 hours of admission and repeat on Day 3. Early (Day 1) SCORTEN may underestimate final severity as BSA detachment and metabolic derangements often peak at 48–72 hours. Both Day 1 and Day 3 scores should be documented.

Related Scores in Practice

In clinical practice, this assessment is frequently evaluated alongside other validated measures. Depending on the patient's presentation and specific diagnostic requirements, you may also need to utilize the RegiSCAR DRESS Validation, AGEP Score, ALDEN Algorithm or the Revised Baux Score to formulate a comprehensive care plan.

Last Comprehensive Review: 2026

Guidelines & Evidence