PrEP Eligibility: CDC-aligned candidacy screen. Reduces HIV transmission risk by >99% in adherent patients.
Step 1: Exposure Risk
Step 2: Lab Readiness
PrEP Eligibility Status
Not a Candidate
Initiate routine HIV screening. Patient does not yet meet specific criteria for PrEP or is missing lab requirements.
Guidelines & Evidence
Clinical Details
Section 1
When to Use
Sexual Exposure (MSM or Heterosexual)
["HIV-positive partner (especially if VL is not suppressed)","Recent bacterial STI (Syphilis, Gonorrhea, Chlamydia)","Inconsistent or no condom use with multiple partners","Commercial sex work"]
Injection Drug Use (IVDU)
["Sharing injection equipment","HIV-positive injection partner","Risk of sexual transmission"]
Section 2
Pre-Initiation
Laboratory Requirements
["Confirmed Negative HIV Test (within 7 days)","No symptoms of acute HIV (Fever, sore throat, rash)","Creatinine Clearance (CrCl) ≥ 60 mL/min (for TDF)","CrCl ≥ 30 mL/min (for TAF/Descovy)","Hepatitis B status (TDF is active against HBV)"]
Section 3
Regimens
Oral Daily PrEP
["Truvada (TDF/FTC): For all groups.","Descovy (TAF/FTC): For MSM and TG women (not validated for cisgender women for vaginal exposure)."]
