HCV Fibrosis FIB4

HCV Fibrosis FIB-4: Cross-linked FIB-4 fibrosis assessment for hepatitis C staging.

FIB-4 Index: Non-invasive marker for liver fibrosis (HCV, HBV, NAFLD). High NPV for ruling out advanced cirrhosis.

Age

yrs

Platelets

x10³/µL

AST

U/L

ALT

U/L

Guidelines & Evidence

Clinical Details

Section 1

When to Use

Use during early bedside triage when infection severity or treatment escalation is uncertain.

Support clinician judgement with a structured review of the highest-yield risk factors.

Standardise communication between admitting, ID, ICU, and pharmacy teams.

Section 2

Formula & Logic

Scoring Logic

Cross-linked to the established scoring engine used elsewhere in OpiCalc.

Section 3

Next Steps

Clinical Actions

Interpret the result together with source control, microbiology, host factors, and trajectory.

Escalate imaging, cultures, or specialist review when the tool lands in a high-risk tier.

Reassess dynamically if the patient deteriorates or new microbiology becomes available.

Section 4

Pearls/Pitfalls

Important Caveat

This tool supports structured infectious-disease decision making but does not replace clinician judgement or local guideline pathways.

Section 5

Evidence Appraisal

Evidence Base

This OpiCalc infectious-disease entry reflects commonly used guideline criteria and bedside risk features used in contemporary clinical practice.

Last Comprehensive Review: 2026

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