Antibiotic PK/PD Optimisation: PK/PD red flags identifying when exposure targets are unlikely to be met.
Assessment Tier
Standard Exposure Likely
Score 0
No major PK/PD exposure flag selected.
Verified
Last Review: 2026-07-17
Use during early bedside triage when infection severity or treatment escalation is uncertain.
Support clinician judgement with a structured review of the highest-yield risk factors.
Standardise communication between admitting, ID, ICU, and pharmacy teams.
Augmented renal clearance (+2)
Obesity / altered Vd (+1)
Critical illness or septic shock (+2)
Deep-seated infection / poor source control (+1)
No therapeutic drug monitoring available (+1)
Interpret the result together with source control, microbiology, host factors, and trajectory.
Escalate imaging, cultures, or specialist review when the tool lands in a high-risk tier.
Reassess dynamically if the patient deteriorates or new microbiology becomes available.
This tool supports structured infectious-disease decision making but does not replace clinician judgement or local guideline pathways.
This OpiCalc infectious-disease entry reflects commonly used guideline criteria and bedside risk features used in contemporary clinical practice.
Last Comprehensive Review: 2026-07-17