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AMD Severity ScaleAstigmatism AssistantBarrett / SRK-T SimDiabetic Retinopathy RiskGlaucoma ProgressionGlaucoma Risk (OHTS)Graves CASHFA MD to VFI ConverterIOP Correction (CCT)LogMAR <-> SnellenMRD AssessmentROP Risk (G-ROP)SPEED Score (Dry Eye)SUN Uveitis GradingVertex Distance
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Graves CAS

Clinical Activity Score

0/7
Inactive Phase
Guidelines & Evidence

Verified

Last Review: 2026-07-17

When to Use

Assessment Goal

The Clinical Activity Score (CAS) is used to determine if thyroid-associated ophthalmopathy (TAO) is in the active, inflammatory phase where immunosuppression (e.g. steroids, Teprotumumab) is most effective.

How it Works

Initial 7 Parameters (1 pt each)

Spontaneous retrobulbar pain
Pain on attempted up or down gaze
Redness of eyelids
Redness of conjunctiva (diffuse)
Swelling of eyelids
Chemosis (swelling of conjunctiva)
Swelling of the caruncle or plica

Interpretation

Active disease is defined as a CAS ≥ 3/7 at the first visit.

Last Comprehensive Review: 2026-07-17

Recent Journal Updates

British J Clinical PharmacologyJul 21, 2026
A university‐certified course on dossier assessment for regulatory scientists in Africa—Reporting on our 5‐year experience

Clinical Context

We think this has broad domain relevance to Graves Ophthalmology CSS.

Cancer MedicineJul 16, 2026
Notch3/4 Knockdown Inhibits Colon Adenocarcinoma Progression by Suppressing Tumor Cell Activity and Orchestrating VEGFA‐Dependent Tumor Immune Microenvironment

Clinical Context

We think this has broad domain relevance to Graves Ophthalmology CSS.

WHO NewsJul 15, 2026
New WHO guidelines: up to 45% of dementia risk could be prevented or delayed

Clinical Context

We think this has broad domain relevance to Graves Ophthalmology CSS.