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MRD Assessment

MRD-1 (Upper Lid)

mm

MRD-2 (Lower Lid)

mm
Guidelines & Evidence

Verified

Last Review: 2026-07-17

How it Works

Definitions

MRD-1: Distance from the upper eyelid margin to the corneal light reflex (Normal: 4-5 mm)
MRD-2: Distance from the corneal light reflex to the lower eyelid margin (Normal: 5 mm)
Palpebral Fissure (PF): MRD-1 + MRD-2

Clinical Interpretation

MRD-1 < 4mm typically defines ptosis. Low MRD-1 with a high MRD-2 may suggest eyelid retraction (e.g., in Graves disease).

Last Comprehensive Review: 2026-07-17

Recent Journal Updates

British J Clinical PharmacologyJul 21, 2026
A university‐certified course on dossier assessment for regulatory scientists in Africa—Reporting on our 5‐year experience

Clinical Context

We think this might be relevant to the clinical guidance for MRD-1 / MRD-2 Assessment.

JAMAJul 21, 2026
Correction to Primary Composite Outcome in a Trial of Transfusion Strategy

Clinical Context

We think this has broad domain relevance to MRD-1 / MRD-2 Assessment.

WHO NewsJul 20, 2026
Road deaths fall by 21% globally but stronger action is needed to save lives

Clinical Context

We think this has broad domain relevance to MRD-1 / MRD-2 Assessment.