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GUPI (Genitourinary Pain Index)

Urological Chronic Pelvic Pain Syndromes

Questionnaire

Pain Symptoms

1. In the last week, have you experienced any pain or discomfort in the following areas? (Check all that apply)

Area between rectum and testicles (perineum)

Testicles

Tip of the penis (not related to urination)

Below your waist, in your pubic or bladder area

2. In the last week, have you experienced: (Check all that apply)

Pain or burning during urination?

Pain or discomfort during or after sexual intercourse?

Pain or discomfort as your bladder fills?

Pain or discomfort relieved by voiding?

3. How often have you had pain or discomfort in any of these areas over the last week?

4. Which number best describes your AVERAGE pain or discomfort on the days you had it, over the last week?

0 = No Pain10 = Worst Possible

Urinary Symptoms

5. How often have you had a sensation of not emptying your bladder completely after you finished urinating, over the last week?

6. How often have you had to urinate again less than two hours after you finished urinating, over the last week?

Quality of Life

7. How much have your symptoms kept you from doing the kinds of things you would usually do, over the last week?

8. How much did you think about your symptoms, over the last week?

9. If you were to spend the rest of your life with your symptoms just the way they have been during the last week, how would you feel about that?

Awaiting Responses

Complete all 9 questions across the pain, urinary, and quality of life subscales to calculate the GUPI.

Guidelines & Evidence

Verified

Last Review: 2026

Overview & Clinical Context

Definition & Clinical Utility

The Genitourinary Pain Index (GUPI) is a validated, patient-reported outcome measure designed to quantify symptom severity in individuals with urological chronic pelvic pain syndromes (UCPPS). It is applicable to both men and women and is widely used in conditions such as interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Why GUPI Matters

Provides standardized assessment of pain, urinary symptoms, and quality of life

Allows objective tracking of symptom progression over time

Facilitates monitoring of treatment response in clinical practice and trials

Applicable to both sexes (unlike original NIH-CPSI)

Correlates strongly with patient global impression of improvement (PGI-I)

Clinical Conditions Where GUPI is Used

Chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS)

Interstitial cystitis / bladder pain syndrome (IC/BPS)

Urological chronic pelvic pain syndrome (UCPPS)

Post-infectious pelvic pain syndromes

Pelvic floor dysfunction with urinary symptoms

Last Comprehensive Review: 2026

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