Verified
Last Review: 2026-07-17
| < 10 mOsm/kgH2O | Normal |
| 10–20 mOsm/kgH2O | Borderline (High clinical suspicion needed) |
| > 20 mOsm/kgH2O | Highly suggestive of toxic alcohol or unmeasured osmole |
Hoffman RS et al. • Annals of Emergency Medicine.. 1993;Demonstrated the utility of the gap while highlighting its poor sensitivity in late-stage presentations.
Krasowski MD et al. • BMC Clinical Pathology.. 2012;Validation of the "Double Gap" approach in clinical practice.
Last Comprehensive Review: 2026-07-17
Clinical Context
We think this might be relevant to the clinical guidance for Osmolality Gap — Toxic Alcohol Screening.
Clinical Context
We think this might be relevant to the clinical guidance for Osmolality Gap — Toxic Alcohol Screening.
Clinical Context
We think this might be relevant to the clinical guidance for Osmolality Gap — Toxic Alcohol Screening.
