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Recent Journal Updates

DiabetologiaJun 5, 2026
MASLD, diabetes and PMOS across the female life stages

Clinical Context

We think this might be relevant to the clinical guidance for Osmolality Gap — Toxic Alcohol Screening.

WHO NewsJun 5, 2026
Africa CDC and WHO launch joint continental Ebola response plan

Clinical Context

We think this might be relevant to the clinical guidance for Osmolality Gap — Toxic Alcohol Screening.

PLOS MedicineJun 4, 2026
Comparative impacts and cost-effectiveness of tuberculosis systematic screening strategies in prisons in Brazil, Colombia, and Peru: A mathematical modeling study

Clinical Context

We think this might be relevant to the clinical guidance for Osmolality Gap — Toxic Alcohol Screening.

Osmolality Gap

Serum Osmolality & Gap: Identifies unmeasured osmols (toxic alcohols).
mOsm/kg
mEq/L
mg/dL
mg/dL
mg/dL
Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

Evaluation of suspected toxic alcohol ingestion (Methanol, Ethylene Glycol, Diethylene Glycol, Propylene Glycol).
Workup of High Anion Gap Metabolic Acidosis (HAGMA) with an unknown etiology.
Suspicion of "Osmotic Diuretics" in circulation (e.g., Mannitol, Sorbitol, Glycerol).
Screening for pseudohyponatremia (extreme hyperlipidemia or hyperproteinemia).

Clinical Threshold

The Osmolality Gap should be interpreted alongside the Anion Gap. A "Double Gap" (elevated Anion Gap and elevated Osmolality Gap) is highly specific for toxic alcohols.

Last Comprehensive Review: 2026

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