HCV Fibrosis FIB-4: Cross-linked FIB-4 fibrosis assessment for hepatitis C staging.
Fibrosis-4 Index (FIB-4 Index)
Non-Invasive Liver Fibrosis Staging
Fibrosis Engine
Enter age, liver enzymes and platelets to execute non-invasive fibrosis triage.
Verified
Last Review: 2026-07-17
Sterling RK et al. • Hepatology. 2006;The landmark study that established the FIB-4 formula and its clinical thresholds.
Shah AG et al. • Clin Gastroenterol Hepatol. 2009;Confirmed FIB-4 accuracy for fatty liver disease, identifying it as a top-performing non-invasive test.
Last Comprehensive Review: 2026-07-17
Verified
Last Review: 2026-07-17
Sterling RK et al. • Hepatology. 2006;The landmark study of 812 patients that established the FIB-4 index. It was originally derived for HIV/HCV patients but was soon validated for HCV mono-infection.
Vallet-Pichard A et al. • Hepatology. 2007;Study of 847 patients that confirmed the high accuracy and negative predictive value of FIB-4 in a pure HCV cohort.
Last Comprehensive Review: 2026-07-17
Clinical Context
We think this has broad domain relevance to HCV Fibrosis FIB-4 Index.
Clinical Context
We think this has broad domain relevance to HCV Fibrosis FIB-4 Index.
Clinical Context
We think this has broad domain relevance to HCV Fibrosis FIB-4 Index.
