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AST-to-Platelet Ratio Index (APRI Score)Acute Liver Failure Study Group Index (ALFSG Index)Age, Bilirubin, INR and Creatinine Score (ABIC Score)Albumin-Bilirubin Grade (ALBI Score)BMI, AST/ALT Ratio, and Diabetes Score (BARD Score)CLIF-C ACLF Score for Acute-on-Chronic Liver Failure (CLIF-C ACLF)CLIF-C AD Score for Acute Decompensation of Cirrhosis (CLIF-C AD)CLIF-SOFA Score for Organ Failure Assessment (CLIF-SOFA)Cancer of the Liver Italian Program Score (CLIP Score)Child-Pugh Classification for Cirrhosis (Child-Pugh)Chinese University Prognostic Index (CUPI Score)Fibrosis-4 Index (FIB-4 Index)Lille Model for Alcoholic Hepatitis (Lille Model)Maddrey Discriminant Function (Maddrey DF)Model for End-Stage Liver Disease (MELD Score)NAFLD Fibrosis Score (NFS)Simplified Autoimmune Hepatitis Score (Simplified AIH)
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Acute Liver Failure Study Group Index (ALFSG Index)

Acute Liver Failure Study Group Index (ALFSG Index)

Prediction of Spontaneous Survival

21-Day Spontaneous Survival Model

ALFSG Engine

Enter admission laboratory and clinical data to predict survival in ALF.

Guidelines & Evidence

Verified

Last Review: 2026

Clinical Significance

Management of Acute Liver Failure

ALF is a catastrophic syndrome defined by the sudden onset of jaundice, coagulopathy, and encephalopathy. Mortality without transplant remains high, making rapid triage essential.

The Importance of Etiology

The cause of ALF is the strongest predictor of outcome. Acetaminophen (APAP) and Hepatitis A have much higher survival rates than idiosyncratic drug injury (DILI) or indeterminate causes.

Transplant-Free Survival

The ALFSG Index helps identify patients who have a high probability of "spontaneous recovery" versus those who require an immediate life-saving liver transplant.

Last Comprehensive Review: 2026

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