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AST-to-Platelet Ratio Index (APRI Score)Acute Liver Failure Study Group Index (ALFSG Index)Age, Bilirubin, INR and Creatinine Score (ABIC Score)Albumin-Bilirubin Grade (ALBI Score)BMI, AST/ALT Ratio, and Diabetes Score (BARD Score)CLIF-C ACLF Score for Acute-on-Chronic Liver Failure (CLIF-C ACLF)CLIF-C AD Score for Acute Decompensation of Cirrhosis (CLIF-C AD)CLIF-SOFA Score for Organ Failure Assessment (CLIF-SOFA)Cancer of the Liver Italian Program Score (CLIP Score)Child-Pugh Classification for Cirrhosis (Child-Pugh)Chinese University Prognostic Index (CUPI Score)Fibrosis-4 Index (FIB-4 Index)Lille Model for Alcoholic Hepatitis (Lille Model)Maddrey Discriminant Function (Maddrey DF)Model for End-Stage Liver Disease (MELD Score)NAFLD Fibrosis Score (NFS)Simplified Autoimmune Hepatitis Score (Simplified AIH)
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Chinese University Prognostic Index (CUPI Score)

Chinese University Prognostic Index (CUPI Score)

HBV-related HCC Prognostic System

Optimized for HBV-related Hepatocellular Carcinoma

CUPI Index

-3
Low Risk

Clinical Prognosis

Low-risk group. Potential candidates for radical therapies such as resection or RFA. Requires MDT review.

Guidelines & Evidence

Verified

Last Review: 2026

Clinical Significance

HBV-Related HCC Staging

In Asia, the majority of HCC is driven by chronic Hepatitis B. These patients have a different clinical profile than Western cohorts. CUPI provides better prognostic discrimination for this demographic.

Granular Risk Groups

By using a weighted point system for seven clinical and laboratory variables, CUPI allows for a very precise survival estimate, helping guide treatment intensity.

The Power of Screening

The CUPI score heavily weights "Asymptomatic Presentation," highlighting the survival benefit of finding HCC via regular ultrasound and AFP screening.

Last Comprehensive Review: 2026

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