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AST-to-Platelet Ratio Index (APRI Score)Acute Liver Failure Study Group Index (ALFSG Index)Age, Bilirubin, INR and Creatinine Score (ABIC Score)Albumin-Bilirubin Grade (ALBI Score)BMI, AST/ALT Ratio, and Diabetes Score (BARD Score)CLIF-C ACLF Score for Acute-on-Chronic Liver Failure (CLIF-C ACLF)CLIF-C AD Score for Acute Decompensation of Cirrhosis (CLIF-C AD)CLIF-SOFA Score for Organ Failure Assessment (CLIF-SOFA)Cancer of the Liver Italian Program Score (CLIP Score)Child-Pugh Classification for Cirrhosis (Child-Pugh)Chinese University Prognostic Index (CUPI Score)Fibrosis-4 Index (FIB-4 Index)Lille Model for Alcoholic Hepatitis (Lille Model)Maddrey Discriminant Function (Maddrey DF)Model for End-Stage Liver Disease (MELD Score)NAFLD Fibrosis Score (NFS)Simplified Autoimmune Hepatitis Score (Simplified AIH)
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NAFLD Fibrosis Score (NFS)

NAFLD Fibrosis Score (NFS)

Fibrosis Prediction in Fatty Liver Disease

Cutoff > 0.676 = Advanced fibrosis (F3–F4)

NAFLD Engine

Enter clinical variables to predict advanced hepatic fibrosis in NAFLD patients.

Guidelines & Evidence

Verified

Last Review: 2026

Clinical Significance

The Global Burden of NAFLD

NAFLD is the most common cause of chronic liver disease globally. While most patients have simple steatosis, those with advanced fibrosis are at the highest risk for cirrhosis, liver failure, and hepatocellular carcinoma.

Avoiding Unnecessary Biopsies

Liver biopsy is invasive and costly. The NFS helps clinicians "rule out" advanced fibrosis with high accuracy, identifying low-risk patients who can be managed in primary care without specialist referral.

The Metabolic Syndrome Link

The NFS specifically incorporates obesity and hyperglycemia (Diabetes status), recognizing that metabolic syndrome is the primary driver of liver scarring in fatty liver disease.

Last Comprehensive Review: 2026

Related Hepatology Tools

Chinese University Prognostic Index
NAFLD Fibrosis Score
CLIF-C ACLF Score for Acute-on-Chronic Liver Failure
Albumin-Bilirubin Grade
Simplified Autoimmune Hepatitis Score
Child-Pugh Classification for Cirrhosis
Model for End-Stage Liver Disease
Cancer of the Liver Italian Program Score
BMI, AST/ALT Ratio, and Diabetes Score
AST-to-Platelet Ratio Index
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