NAFLD Fibrosis Score (NFS)

NAFLD is the most common cause of chronic liver disease globally. While most patients have simple steatosis, those with advanced fibrosis are at the highest risk for cirrhosis, liver failure, and hepatocellular carcinoma.

Liver biopsy is invasive and costly. The NFS helps clinicians "rule out" advanced fibrosis with high accuracy, identifying low-risk patients who can be managed in primary care without specialist referral.

The NFS specifically incorporates obesity and hyperglycemia (Diabetes status), recognizing that metabolic syndrome is the primary driver of liver scarring in fatty liver disease.