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AST-to-Platelet Ratio Index (APRI Score)Acute Liver Failure Study Group Index (ALFSG Index)Age, Bilirubin, INR and Creatinine Score (ABIC Score)Albumin-Bilirubin Grade (ALBI Score)BMI, AST/ALT Ratio, and Diabetes Score (BARD Score)CLIF-C ACLF Score for Acute-on-Chronic Liver Failure (CLIF-C ACLF)CLIF-C AD Score for Acute Decompensation of Cirrhosis (CLIF-C AD)CLIF-SOFA Score for Organ Failure Assessment (CLIF-SOFA)Cancer of the Liver Italian Program Score (CLIP Score)Child-Pugh Classification for Cirrhosis (Child-Pugh)Chinese University Prognostic Index (CUPI Score)Fibrosis-4 Index (FIB-4 Index)Lille Model for Alcoholic Hepatitis (Lille Model)Maddrey Discriminant Function (Maddrey DF)Model for End-Stage Liver Disease (MELD Score)NAFLD Fibrosis Score (NFS)Simplified Autoimmune Hepatitis Score (Simplified AIH)
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AST-to-Platelet Ratio Index (APRI Score)

AST-to-Platelet Ratio Index (APRI Score)

HCV Fibrosis Screening Matrix

Optimized for Hepatitis C staging

Composite Score

0
Lower Risk

Clinical Path

Advanced fibrosis is less likely based on the selected clinical profile. Annual surveillance sufficient.

Guidelines & Evidence

Verified

Last Review: 2026

Clinical Significance

Screening for HCV-Related Fibrosis

The APRI score was developed to provide a cost-effective alternative to liver biopsy for staging fibrosis in patients with chronic Hepatitis C. It is particularly useful in resource-limited settings where specialized tests like FibroScan or the ELF score are unavailable.

Predicting Cirrhosis

A high APRI score is strongly associated with advanced fibrosis and cirrhosis. Identifying these patients is critical for deciding on treatment urgency and initiating HCC surveillance.

Rule-Out Capability

Like FIB-4, the primary utility of APRI is its high Negative Predictive Value (NPV), which allows clinicians to "rule out" significant fibrosis in patients with low scores.

Last Comprehensive Review: 2026

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Maddrey Discriminant Function
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CLIF-C AD Score for Acute Decompensation of Cirrhosis
Acute Liver Failure Study Group Index
Model for End-Stage Liver Disease
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