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AST-to-Platelet Ratio Index (APRI Score)Acute Liver Failure Study Group Index (ALFSG Index)Age, Bilirubin, INR and Creatinine Score (ABIC Score)Albumin-Bilirubin Grade (ALBI Score)BMI, AST/ALT Ratio, and Diabetes Score (BARD Score)CLIF-C ACLF Score for Acute-on-Chronic Liver Failure (CLIF-C ACLF)CLIF-C AD Score for Acute Decompensation of Cirrhosis (CLIF-C AD)CLIF-SOFA Score for Organ Failure Assessment (CLIF-SOFA)Cancer of the Liver Italian Program Score (CLIP Score)Child-Pugh Classification for Cirrhosis (Child-Pugh)Chinese University Prognostic Index (CUPI Score)Fibrosis-4 Index (FIB-4 Index)Lille Model for Alcoholic Hepatitis (Lille Model)Maddrey Discriminant Function (Maddrey DF)Model for End-Stage Liver Disease (MELD Score)NAFLD Fibrosis Score (NFS)Simplified Autoimmune Hepatitis Score (Simplified AIH)
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Age, Bilirubin, INR and Creatinine Score (ABIC Score)

Age, Bilirubin, INR and Creatinine Score (ABIC Score)

Alcoholic Hepatitis Prognostic Model

Score > 9.0 = High 90-day Mortality

ABIC Calculator

Enter clinical data to predict 90-day survival in alcoholic hepatitis.

Guidelines & Evidence

Verified

Last Review: 2026-07-17

Clinical Significance

Management of Alcoholic Hepatitis

Alcoholic hepatitis is a severe clinical syndrome characterized by jaundice and liver failure. Mortality in severe cases can exceed 40% at 1 month. Accurate risk stratification is vital for deciding on aggressive treatments like corticosteroids.

Beyond the Maddrey DF

While the Maddrey Discriminant Function (mDF) is the gold standard for initiating steroids, it is a binary "severe vs non-severe" tool. The ABIC score provides a continuous risk scale, allowing for more granular patient management.

Age and Kidney Function

ABIC recognizes that Age and Renal function (Creatinine) are independent predictors of survival in AH—two factors that the traditional Maddrey score ignores.

How it Works

Variables Required

Age: Years.
Serum Bilirubin: mg/dL.
Serum Creatinine: mg/dL.
INR: Clotting function.

The Scoring Formula

ABIC Score = (Age × 0.1) + (Bilirubin × 0.08) + (Creatinine × 0.3) + (INR × 0.8)

Risk Stratification (90-day Survival)

Low Risk (< 6.71): 100% survival. Intermediate Risk (6.71–9.0): 70% survival. High Risk (> 9.0): 25% survival.

Clinical Pearls

The Intermediate Group

The "Intermediate" group (6.71–9.0) is the most clinically relevant for steroid therapy. These patients have a high enough risk to justify treatment, but are "salvageable" enough to respond.

Sepsis Vigilance

Infection is the leading cause of death in AH patients on steroids. Perform a "sepsis screen" (paracentesis, CXR, urine culture) before starting prednisolone.

Creatinine Accuracy

Creatinine can be falsely low in cirrhotic patients due to muscle wasting. A "normal" creatinine of 1.0 mg/dL may actually represent significant renal impairment in an emaciated patient.

Next Steps

Moderate-to-Severe AH Management

Initiate Prednisolone 40 mg/day if mDF ≥ 32 and no contraindications.
Aggressive nutritional support (1.2-1.5 g protein/kg/day).
Referral to addiction specialists for alcohol abstinence.
Monitor for alcohol withdrawal (CIWA protocol).

Dynamic Assessment

If on steroids, calculate the Lille Score at Day 7. If the Lille score is > 0.45, steroids should be discontinued as they are likely futile.

The Evidence

Original Validation

A new prognostic model for alcoholic hepatitis: the ABIC score.

Dominguez M et al. • Gastroenterology. 2008;Developed in a Spanish cohort and validated internationally. Proved that ABIC was more accurate than MELD or Maddrey in predicting 90-day outcomes.

Global Comparison

Prognostic models of acute alcoholic hepatitis.

Papastergiou V et al. • World J Gastroenterol. 2014;Systematic review confirming that ABIC and MELD are superior to the Maddrey DF for short-term mortality prediction.

Origins & History

The Barcelona Model

The ABIC score was developed at the Hospital Clinic of Barcelona. The acronym stands for the components: Age, Bilirubin, INR, and Creatinine.

Moving Towards Continuous Scoring

Its creation marked a shift in hepatology from using simple cutoffs (like the Maddrey 32) toward weighted multivariable models that more accurately reflect the complexity of liver failure.

Last Comprehensive Review: 2026-07-17

In Recent Clinical News

Scanning Medical Journals

No new significant updates or guidelines matching this topic were found today. We will check again soon.