Fibrosis-4 Index (FIB-4 Index)

Liver fibrosis is the strongest predictor of outcomes in chronic liver disease. The FIB-4 index allows for rapid, cost-free screening of large populations to identify those at risk for cirrhosis.

FIB-4 has a very high Negative Predictive Value (NPV), meaning it can safely "rule out" advanced fibrosis in the majority of patients, sparing them from invasive liver biopsies.

Because it uses only standard labs (CBC/CMP), FIB-4 is the preferred first-line tool for primary care physicians managing NAFLD/MASLD and Hepatitis C.