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AST-to-Platelet Ratio Index (APRI Score)Acute Liver Failure Study Group Index (ALFSG Index)Age, Bilirubin, INR and Creatinine Score (ABIC Score)Albumin-Bilirubin Grade (ALBI Score)BMI, AST/ALT Ratio, and Diabetes Score (BARD Score)CLIF-C ACLF Score for Acute-on-Chronic Liver Failure (CLIF-C ACLF)CLIF-C AD Score for Acute Decompensation of Cirrhosis (CLIF-C AD)CLIF-SOFA Score for Organ Failure Assessment (CLIF-SOFA)Cancer of the Liver Italian Program Score (CLIP Score)Child-Pugh Classification for Cirrhosis (Child-Pugh)Chinese University Prognostic Index (CUPI Score)Fibrosis-4 Index (FIB-4 Index)Lille Model for Alcoholic Hepatitis (Lille Model)Maddrey Discriminant Function (Maddrey DF)Model for End-Stage Liver Disease (MELD Score)NAFLD Fibrosis Score (NFS)Simplified Autoimmune Hepatitis Score (Simplified AIH)
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In Recent Clinical News

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Fibrosis-4 Index (FIB-4 Index)

Fibrosis-4 Index (FIB-4 Index)

Non-Invasive Liver Fibrosis Staging

Formula: (Age × AST) / (Platelets × √ALT)

Fibrosis Engine

Enter age, liver enzymes and platelets to execute non-invasive fibrosis triage.

Guidelines & Evidence

Verified

Last Review: 2026

Clinical Significance

Screening for Advanced Fibrosis

Liver fibrosis is the strongest predictor of outcomes in chronic liver disease. The FIB-4 index allows for rapid, cost-free screening of large populations to identify those at risk for cirrhosis.

Reducing Biopsy Burden

FIB-4 has a very high Negative Predictive Value (NPV), meaning it can safely "rule out" advanced fibrosis in the majority of patients, sparing them from invasive liver biopsies.

Primary Care Utility

Because it uses only standard labs (CBC/CMP), FIB-4 is the preferred first-line tool for primary care physicians managing NAFLD/MASLD and Hepatitis C.

Last Comprehensive Review: 2026

Related Hepatology Tools

Cancer of the Liver Italian Program Score
Fibrosis-4 Index
NAFLD Fibrosis Score
CLIF-C ACLF Score for Acute-on-Chronic Liver Failure
Acute Liver Failure Study Group Index
BMI, AST/ALT Ratio, and Diabetes Score
AST-to-Platelet Ratio Index
Lille Model for Alcoholic Hepatitis
Maddrey Discriminant Function
Chinese University Prognostic Index
Hepatology CalculatorsInternal Medicine CalculatorsEmergency Medicine Calculators
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