CLIF-SOFA Score for Organ Failure Assessment (CLIF-SOFA)

Acute-on-Chronic Liver Failure (ACLF) is not just worsening cirrhosis; it is a systemic inflammatory syndrome with organ failure. CLIF-SOFA provides the objective definition for when an organ system has officially "failed" in a cirrhotic patient.

The standard SOFA score used in general ICUs is less accurate for cirrhotic patients. CLIF-SOFA incorporates INR and the West Haven encephalopathy scale, which are more relevant than platelets and GCS for this population.

By assessing six organ systems simultaneously, CLIF-SOFA accurately predicts short-term mortality, helping to guide decisions about ICU intensity and transplant urgency.