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AST-to-Platelet Ratio Index (APRI Score)Acute Liver Failure Study Group Index (ALFSG Index)Age, Bilirubin, INR and Creatinine Score (ABIC Score)Albumin-Bilirubin Grade (ALBI Score)BMI, AST/ALT Ratio, and Diabetes Score (BARD Score)CLIF-C ACLF Score for Acute-on-Chronic Liver Failure (CLIF-C ACLF)CLIF-C AD Score for Acute Decompensation of Cirrhosis (CLIF-C AD)CLIF-SOFA Score for Organ Failure Assessment (CLIF-SOFA)Cancer of the Liver Italian Program Score (CLIP Score)Child-Pugh Classification for Cirrhosis (Child-Pugh)Chinese University Prognostic Index (CUPI Score)Fibrosis-4 Index (FIB-4 Index)Lille Model for Alcoholic Hepatitis (Lille Model)Maddrey Discriminant Function (Maddrey DF)Model for End-Stage Liver Disease (MELD Score)NAFLD Fibrosis Score (NFS)Simplified Autoimmune Hepatitis Score (Simplified AIH)
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In Recent Clinical News

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CLIF-SOFA Score for Organ Failure Assessment (CLIF-SOFA)

CLIF-SOFA Score for Organ Failure Assessment (CLIF-SOFA)

Modified SOFA for Cirrhotic ICU Patients

Subscore ≥ 3 = Critical Organ Failure

Total SOFA

0

Organ Failures

0

Clinical Status

No organ failure identified by CLIF-C criteria. Continue supportive care and daily monitoring.

Guidelines & Evidence

Verified

Last Review: 2026

Clinical Significance

Diagnosis of ACLF

Acute-on-Chronic Liver Failure (ACLF) is not just worsening cirrhosis; it is a systemic inflammatory syndrome with organ failure. CLIF-SOFA provides the objective definition for when an organ system has officially "failed" in a cirrhotic patient.

A Liver-Specific ICU Tool

The standard SOFA score used in general ICUs is less accurate for cirrhotic patients. CLIF-SOFA incorporates INR and the West Haven encephalopathy scale, which are more relevant than platelets and GCS for this population.

Prognostic Power

By assessing six organ systems simultaneously, CLIF-SOFA accurately predicts short-term mortality, helping to guide decisions about ICU intensity and transplant urgency.

Last Comprehensive Review: 2026

Related Hepatology Tools

CLIF-SOFA Score for Organ Failure Assessment
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AST-to-Platelet Ratio Index
Simplified Autoimmune Hepatitis Score
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Albumin-Bilirubin Grade
Cancer of the Liver Italian Program Score
NAFLD Fibrosis Score
Chinese University Prognostic Index
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